Results 51 to 60 of about 27,277 (237)

Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Emerging evidence suggests that C3aR (C3a anaphylatoxin receptor) signaling has protective roles in various inflammatory-related diseases.
Linlin Wei, N. Ma, Kunyi Wu, Jia-Xing Wang, Teng-yue Diao, Shu-Juan Zhao, Liang Bai, Enqi Liu, Zong-fang Li, Wuding Zhou, Daxin Chen, Ke Li   +11 more
semanticscholar   +1 more source

AgBF4‐Induced Site‐Selective Synthesis of 4‐Sulfonylindoles in Au‐Catalyzed Cyclization‐Sulfonyl Migration Reactions

Chemistry – A European Journal, EarlyView.
Site‐selective synthesis 4‐suflonylindoles was achieved by a cyclization‐rearrangement strategy by π‐Lewis acidic gold catalysts and the aid of silver cocatalyst. Particularly, the use of 3 equivalents of AgBF4 to SPhosAuCl is crucial for C4‐selective migration of the sulfonyl group.
Itaru Nakamura, Chunbo Jia, Masahiro Terada   +2 more
wiley   +1 more source

Late Pruning and Forced Vine Regrowth in Chardonnay and Pinot Noir: Benefits and Drawbacks in the Trento DOC Basin (Italy)

Agronomy, 2023
Targeted pruning techniques may have the potential to shift phenological progression in grapevines. These approaches can be useful to escape late frost (after budburst) and to delay ripening, maintaining yield and berry quality under specific ...
Massimo Bertamini, Michele Faralli
doaj   +1 more source

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor [PDF]

Bioconjugate Chemistry, 2017
Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo, Chongyang Wu, Kai-Chen Wu, Robert C. Reid, Thomas Durek, Junxian Lim, David P. Fairlie   +6 more
openaire   +3 more sources

Synthesis, Crystal Structure, and Optoelectronic Properties of [(n‐/tert‐C4H9)S(CH3)2]PbI3

European Journal of Inorganic Chemistry, EarlyView.
Reaction of two isomers of butyldimethylsulfonium cation with PbI2 using solid‐state and solution methods yielded the corresponding organic/inorganic hybrid compounds with high humidity tolerance and 1D crystal structures of [n‐C4H9S(CH3)2]PbI3 and [tert‐C4H9S(CH3)2]PbI3.
Ioannis Koutsoumpogeras, Nikolaos Tsoureas, Nagia S. Tagiara, Ioannis Koutselas, Andreas Kaltzoglou   +4 more
wiley   +1 more source

Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. [PDF]

PLoS ONE, 2017
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important
Pamela S Hair, Laura A Sass, Turaj Vazifedan, Tushar A Shah, Neel K Krishna, Kenji M Cunnion   +5 more
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Enzymatic Synthesis of Demethylated Sesquiterpenes From 14‐nor‐Farnesyl Pyrophosphate

European Journal of Organic Chemistry, EarlyView.
The substrate analog 14‐nor‐FPP was synthesised and enzymatically converted with 10 bacterial and fungal sesquiterpene synthases, resulting in the isolation of 12 demethylated sesquiterpenes in yields up to 17%. In most cases the demethyl analogs of the FPP‐derived natural products were obtained, but also different products showing modified ...
Kizerbo A. Taizoumbe, Jeroen S. Dickschat   +1 more
wiley   +1 more source

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Scientific Reports, 2021
We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +13 more
doaj   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Allali S, Sbeih N, Rignault-Bricard R, Bruce J, Gall ML, Heilbronner C, de Cacqueray N, Angyalosy S, Taylor M, Brice J, de Montalembert M, Bevacqua M, Gautier EF, Hermine O, Maciel TT.   +14 more
europepmc   +2 more sources