Results 101 to 110 of about 853,917 (241)

IN VITRO STUDIES OF COMPLEMENT FUNCTION IN SERA OF C4-DEFICIENT GUINEA PIGS [PDF]

open access: bronze, 1971
Michael M. Frank   +3 more
openalex   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

open access: yesAdvanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang   +5 more
wiley   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

The Reaction C4-Olefins with Formaldehyde

open access: bronze, 1963
Hideo Noda, Toshio Takino, Kenichi Fukui
openalex   +2 more sources

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

open access: yesAdvanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen   +7 more
wiley   +1 more source

Human C4-binding protein. Association with immune complexes in vitro and in vivo. [PDF]

open access: bronze, 1979
Júlio Scharfstein   +3 more
openalex   +1 more source

Thermomagnetic analysis of meteorites. 3: C3 and C4 chondrites [PDF]

open access: yes
Thermomagnetic analysis on all of the C3 and C4 chondrites, conducted under conditions of controlled oxygen fugacity, indicates the presence of a thermally unstable component in at least 5 of the C3 chondrites which upon heating results in magnetite ...
Herndon, J. M.   +3 more
core   +1 more source

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