Results 121 to 130 of about 364,632 (296)

Experimental studies in a reconfigurable C4 test-bed for network enabled capability

, 2006
This paper reports on the development of a command and control environment that enables experimental studies to be conducted into Network Enabled Capability (NEC).
Stanton, Neville A., Baber, C., Gulliver, S., Houghton, R., Rafferty, Laura, Salmon, P.M, Cross, J., Jenkins, D., Walker, G.H, Young, M.S., Watts, S., McMaster, R., Ladva, Darshna   +12 more
core  

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Communications Chemistry
PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models.
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort   +28 more
doaj   +1 more source

Leaf transcriptomes from C3, C3-C4 intermediate, and C4 Neurachne species give insights into C4 photosynthesis evolution.

Lauterbach M, Bräutigam A, Clayton H, et al. Leaf transcriptomes from C3, C3-C4 intermediate, and C4 Neurachne species give insights into C4 photosynthesis evolution. Plant physiology.
Saladie, Montserrat, Clayton, Harmony, Rolland, Vivien, Weber, Andreas P M, Lauterbach, Maximilian, Macfarlane, Terry D, Bräutigam, Andrea ; https://orcid.org/, Ludwig, Martha   +7 more
core   +1 more source

Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice

, 2002
Mice with a disrupted C4 locus (C4!/!) have an impaired immune response to thymus-dependent Ags. To test the role of bone marrow-derived C4 in humoral immunity, we reconstituted deficient animals with wild-type bone marrow or an enriched fraction of bone
Li Ming Shen, Mark A. Brockman, Heather Jezak, Mihaela Gadjeva, Admar Verschoor, Michael C. Carroll, David M. Knipe   +6 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Comparative Oligo‐FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years

Advanced Science, EarlyView.
Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He, Hainan Zhao, Xiaoxue Zeng, Zujun Yang, Wenting Li, Guoyan Zhang, Guangrong Li, Jian He, Bin Guan, Jiming Jiang   +9 more
wiley   +1 more source

Probabilistic Water Quality Monitoring Using Multi-Temporal Sentinel-2 Data: A Situational Awareness Framework for Harmful Algal Bloom Forecasting

Remote Sensing
Environmental monitoring systems require robust uncertainty quantification for effective decision-making in complex ecological processes. Harmful algal blooms represent a critical challenge where prediction uncertainty directly impacts resource ...
Muhammad Zaid Qamar, Cristiano Ciccarelli, Mohammed Ajaoud, Massimiliano Lega   +3 more
doaj   +1 more source

一种混合C4水合制丁醇的方法

, 2004
一种由混合C4馏分在分子筛或改性分子筛为活性组份的催化剂上进行水合的方法。反应采用高压液相固定床工艺。原料是石油加工过程中生产的C4馏分，或者是C4馏分经MTBE处理后混合C4，也可以是某一单一C4烯烃，催化剂以酸性分子筛或经金属盐或氧化物改性的分子筛为活性组份，以分子筛为活性组份的固体酸催化剂在相应的条件下对 C4烯烃的水合有较好的催化活性和选择性，物料不需提浓，催化剂可以再生 ...
陈刚, 刘中民, 黄韬, 王华
core  

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source