Results 141 to 150 of about 1,190,759 (343)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Trajectory Planning of a Mother Ship Considering Seakeeping Indices to Enhance Launch and Recovery Operations of Autonomous Drones

Oceans
This research focuses on integrating seakeeping indices into the trajectory planning of a mother ship in order to minimize risks during UAV (unmanned aerial vehicle) takeoff and landing in challenging sea conditions.
Salvatore Rosario Bassolillo, Egidio D’Amato, Salvatore Iacono, Silvia Pennino, Antonio Scamardella   +4 more
doaj   +1 more source

Disruption of a Gene Encoding C4-Dicarboxylate Transporter-Like Protein Increases Ozone Sensitivity Through Deregulation of the Stomatal Response in Arabidopsis thaliana [PDF]

, 2007
Shoko Saji, S. Bathula, Akihiro Kubo, Masanori Tamaoki, Machi Kanna, Mitsuko Aono, Nobuyoshi Nakajima, Tatsuro Nakaji, Tomoyuki Takeda, Munehiko Asayama, Hikaru Saji   +10 more
openalex   +1 more source

Centenarian longevity is positively correlated with IgE levels but negatively correlated with C3/C4 levels, abdominal obesity and metabolic syndrome [PDF]

, 2020
Shihui Fu, Yulong Li, Fu Zhang, Fuxin Luan, Faqin Lv, Juelin Deng, Yali Zhao, Yao Yao   +7 more
openalex   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Characterization of a De Novo Conversion in Human Complement C4 Gene Producing a C4B5-Like Protein [PDF]

, 2002
Taina Jaatinen, Miia Eholuoto, Tarja Laitinen, Marja‐Liisa Lokki   +3 more
openalex   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

On Distance Magic Harary Graphs

, 2018
This paper establishes two techniques to construct larger distance magic and (a, d)-distance antimagic graphs using Harary graphs and provides a solution to the existence of distance magicness of legicographic product and direct product of G with C4, for
Paramasivam, Krishnan, Prajeesh, A V
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