Results 251 to 260 of about 364,632 (296)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +1 more source

Can the Stand-Alone Cervical Interfacet Fusion Achieve Spinal Stability? A Comprehensive Finite Element Analysis. [PDF]

Int J Spine Surg
Ciriello L, Rotondi M, Sciarrone GJ, Villa T.   +3 more
europepmc   +1 more source

3‐Deoxy‐3‐Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour

Angewandte Chemie, EarlyView.
The impact of C‐3 fluorination on the synthesis and conformation of alginate oligosaccharides is investigated. A C‐3‐fluoro mannuronic acid building block is generated and shown to react with high β‐selectivity. Automated glycan assembly enables access to uniquely fluorinated mannuronic acid alginates where deoxyfluorination is shown not to perturb the
Sean T. Evans, Nishu Yadav, Wouter A. Remmerswaal, Daan Hoogers, Koen N. A. van de Vrande, Sarah Hosking, Ana Poveda, Jeroen D. C. Codée, Jesús Jiménez‐Barbero, Martina Delbianco, Gavin J. Miller   +10 more
wiley   +1 more source

7-<i>tert</i>-Butyl-1,3-bis-(eth-oxy-meth-yl)pyrene. [PDF]

IUCrdata
Moriguchi T, Sasaki M, Miyoshi N.
europepmc   +1 more source

Non‐Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis

Angewandte Chemie, EarlyView.
Confinement catalysis within a hexameric resorcin[4]arene capsule enables macrolactonization under non‐dilute conditions (up to 0.1 M), overcoming the limitations of high‐dilution protocols (0.1–10 mM). This strategy provides direct access to 18–32‐membered macrodiolides and 26–32‐membered macrotetrolides in one pot and unlocks previously inaccessible ...
Feng‐Yuan Wang, Alessandro Prescimone, Daniel Häussinger, Konrad Tiefenbacher   +3 more
wiley   +1 more source

Crystal and mol-ecular structures of datiscetin and its monohydrate isolated from <i>Datisca cannabina</i> L. [PDF]

Acta Crystallogr E Crystallogr Commun
Akhmedova DS, Turgunov KK, Nishanbaev SZ.   +2 more
europepmc   +1 more source

Transition Metal‐Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones

Angewandte Chemie, EarlyView.
A transition metal‐free insertion of five‐membered heteroarenes into the C─C bonds of benzocyclobutenones has been achieved under mild and operationally simple conditions. This method provides an efficient and modular approach to access fused partially saturated hetero‐polycyclic scaffolds that exist in many bioactive molecules.
Cole J. Wagner, Guangbin Dong
wiley   +1 more source

2-[(2,5-Di-methyl-phen-yl)amino]-quinoline-3-carb-oxy-lic acid. [PDF]

IUCrdata
Ji X, Long S.
europepmc   +1 more source

1,7‐Digallatetracarborane: Between Nucleophilic closo‐Cluster and “Inverse Sandwich” Digallylene

Angewandte Chemie, EarlyView.
A dianionic π‐ligand is used to make a Janus‐type twofold complex with low‐valent gallium Ga(+I). The resulting compound can be seen as and reveals the reactivity of both: a Wade‐type closo‐carborane cluster with nucleophilic Ga‐sites, as well as π‐ligand stabilized Ga(I) atoms in an inverse sandwich compound.
Julijan Sarcevic, Tobias Heitkemper, Niklas Mehner, Maximilian Kubis, Christian P. Sindlinger   +4 more
wiley   +1 more source

Diagnostic performance of indigo carmine-assisted texture and color enhanced magnified imaging for superficial non-ampullary duodenal epithelial tumors. [PDF]

Ther Adv Gastroenterol
Okimoto K, Matsusaka K, Matsumura T, Ishikawa T, Ohashi T, Goto C, Horio R, Kurosugi A, Sonoda M, Oura H, Kaneko T, Ohta Y, Taida T, Ikeda JI, Kato J.   +14 more
europepmc   +1 more source