Results 11 to 20 of about 27,324 (243)

Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D [PDF]

Communications Biology
Recent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Xiaowei Hu, Bobbie-Jo M. Webb-Robertson, Hemang M. Parikh, Ernesto S. Nakayasu, Suna Onengut-Gumuscu, Wei-Min Chen, Ashley Frazer-Abel, Thomas O. Metz, Stephen S. Rich, Marian J. Rewers, Ani Manichaikul   +10 more
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Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes [PDF]

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón‐Aznar, José Luís Callejas-Rubio, Anastasiia Kozlova, Susanna Proudman, Mandana Nikpour, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L. Herrick, Yannick Allanore, Marta E. Alarcón‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P. Denton, Maureen D. Mayes, Javier Martín, Marialbert Acosta‐Herrera, Martin Kerick, Martin Kerick   +22 more
openalex   +2 more sources

Complement C4, C4A and C4a – What they do and how they differ

Brain, Behavior, & Immunity - Health
Meike Heurich, Melanie Föcking, David Cotter   +2 more
doaj   +5 more sources

C4A [PDF]

, 2019
Axel M. Gressner, Torsten Arndt
openalex   +2 more sources

Separation performance of PEG-linked calix[4]arene as stationary phase for capillary gas chromatography [PDF]

Química Nova, 2023
This work presented a new PEG modified calix[4]arene stationary phase (C4A-PEG-2PTSC) for gas chromatographic (GC) separations. The statically coated C4A-PEG-2PTSC column exhibited moderate polarity and column efficiency of 2224 plates m-1 determined by ...
Wei Zhang, Zhiqiang Cai, Wei Li, Qiuchen Huang, Ruonan Chen, Yiwen Li, Keyun Jin, Yi Zhao, Tao Sun   +8 more
doaj   +1 more source

Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery

Pharmaceutics, 2023
Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone 4a (C4a).
Glaucio Valdameri, Diogo Henrique Kita, Julia de Paula Dutra, Diego Lima Gomes, Arun Kumar Tonduru, Thales Kronenberger, Bruno Gavinho, Izadora Volpato Rossi, Mariana Mazetto de Carvalho, Basile Pérès, Ingrid Fatima Zattoni, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Rilton Alves de Freitas, Antti Poso, Suresh V. Ambudkar, Marcel I. Ramirez, Ahcène Boumendjel, Vivian Rotuno Moure   +18 more
doaj   +1 more source

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Genome Biology, 2023
Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A ...
Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson, Michael J. Gandal   +11 more
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Schizophrenia risk loci from xMHC region were associated with antipsychotic response in chronic schizophrenic patients with persistent positive symptom

Translational Psychiatry, 2022
We examined whether common variants from the extended major histocompatibility complex (xMHC) region contribute to the response to antipsychotic drugs (APDs) in patients with schizophrenia with persistent psychosis. Subjects participated in a prospective
Jiang Li, Akane Yoshikawa, Ney Alliey-Rodriguez, Herbert Y. Meltzer   +3 more
doaj   +1 more source

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

Increased activation product of complement 4 protein in plasma of individuals with schizophrenia

Translational Psychiatry, 2021
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban   +14 more
doaj   +1 more source