The Immune Microenvironment of Transplant Glomerulitis. [PDF]
Bracey NA +10 more
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Incomplete Immune Tolerance in Pediatric ABO-Incompatible Liver Transplantation: Insights From Donor-Specific Antibody Titers. [PDF]
Qu W +6 more
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Complement in Antibody-Mediated Rejection of the Kidney Graft: From Pathophysiology to Clinical Practice. [PDF]
Sorohan BM +7 more
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IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation. [PDF]
Xia R +8 more
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A Highly Portable Smartphone-Based Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection. [PDF]
Tao Z +7 more
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C4d in IgA nephropathy: a marker sans boundaries.
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In acute rejection after renal transplant, glomerulitis is characterized by mononuclear cells in glomerular capillaries and endothelial cell enlargement. In association with C4d deposition in peritubular capillaries, glomerulitis is a feature of acute antibody-mediated rejection. Prognosis in C4d(+) rejection is poorer than in C4d(-) rejection.
Aiello FB +9 more
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C4d—The Witness of Humoral Rejection
Transplantation Proceedings, 2009Acute antibody-mediated (humoral) rejection is a major cause of morbidity, graft loss, and mortality among heart transplant patients. Herein we have presented our experience using C4d to characterize humoral rejection.All nonformalin-fixed cardiac graft biopsies (protocol or emergency) received between May 2007 and May 2008 were examined by ...
R H, de Gouveia +6 more
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C4d Immunohistochemistry in glomerulonephritis with different antibodies
Clinical and Experimental Nephrology, 2007The presence of C4d in the kidney is generally detected particularly for the diagnosis of antibody-mediated rejection in renal transplants. In frozen sections of immunofluorescence (IF) staining with anti-C4d monoclonal antibodies (mAbs), we noted intrinsic C4d deposition even in normal glomeruli though their pathogenic or an intrinsic role is unkown ...
Taisei, Suzuki +7 more
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C4d in Native Glomerular Diseases
American Journal of Nephrology, 2019Complement activation occurs in many glomerular diseases, the exact pathway(s) of activation has been studied in detail in some diseases but not in all. C4d is generated by the activation of classical and lectin pathways, and its presence can point to the activation of either of these pathways.
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