Results 141 to 150 of about 6,868 (161)

Urinary C4d Does Not Correlate With C4d-Staining in Peritubular Capillaries But Reflects Nonspecific Glomerular Injury

Transplantation, 2008
C4d-staining in peritubular capillaries (PTC) in allograft biopsies is a hallmark of antibody-mediated rejection (AMR). This study investigated whether urinary C4d correlates with C4d-staining in PTC, allowing for a noninvasive screening procedure.Urine samples from 34 patients with diffuse C4d-staining in PTC (C4d-pos group) and 68 urine samples from ...
Hönger, G., Mayr, M., Dickenmann, M., Mihatsch, M. J., Schaub, S.   +4 more
openaire   +2 more sources

C4d as a Practical Marker for Cutaneous Amyloidosis

The American Journal of Dermatopathology, 2021
Abstract: Cutaneous amyloidosis (CA) is defined by the accumulation of amyloid in the dermis; it might be primary or secondary. The diagnosis is based on histopathological findings with the demonstration of amyloid deposits, confirmed by Congo red stain under the polarized light.
Banu Yaman, Banu Sarsık Kumbaracı, Claudia A. Gómez González, Taner Akalın, Sait Şen   +4 more
openaire   +3 more sources

Diagnostic value of C4d in renal biopsies

Current Opinion in Nephrology & Hypertension, 2005
Capillary C4d is now an established marker of antibody-mediated rejection in graft biopsies. The technique is widely used to further define the clinical relevance of humoral alloreactivity in various patient subgroups. These include highly sensitized patients, recipients with late graft failure and also some with 'stable' graft function.The C4d ...
Helmut E, Feucht, Michael J, Mihatsch
openaire   +2 more sources

C4d: A Marker for Hepatic Transplant Rejection

Transplantation Proceedings, 2006
Acute rejection is still a common complication of hepatic transplantation. The diagnosis, based on the histological examination of the graft, may be difficult to confirm in the setting of combined hepatitis C virus infection. The presence of C4d in the portal capillaries could facilitate differentiation between acute rejection and relapsed hepatitis C.
R, Lorho, B, Turlin, N, Aqodad, N, Triki, A S, de Lajarte-Thirouard, C, Camus, M, Lakehal, P, Compagnon, E, Dupont-Bierre, B, Meunier, K, Boudjema, M, Messner   +11 more
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Clinical and Prognostic Significance of C3d and C4d Positive Immunopathology Pattern Versus C4d Positive Alone

The Journal of Heart and Lung Transplantation, 2013
Purpose Immunopathologic evidence of complement activation is important for the diagnosis of antibody mediated rejection. Two long-lasting complement split products are routinely assayed in biopsies, C3d & C4d. Since C4 cleavage precedes C3 cleavage in the complement cascade, detecting both C3d and C4d in tissue suggests complement activation has run ...
D.V. Miller, M.D. Everitt, K.M. Molina, R. Alharethi, D. Budge, B. Wachter, J. Stehlik, E.M. Gilbert, S.G. Drakos, J.N. Nativi, M.P. Revelo, M.E.H. Hammond, A.G. Kfoury   +12 more
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C4d Deposition in Cardiac Allografts Correlates With Alloantibody

The Journal of Heart and Lung Transplantation, 2005
The presence of C4d along the peritubular capillaries in kidney allografts correlates with the presence of anti-donor serum alloantibodies. We applied C4d staining to cardiac allograft and non-allograft biopsies to determine if C4d staining in heart allografts correlates with anti-donor serum alloantibodies.We stained for C4d all available frozen ...
Rex Neal, Smith, Nicole, Brousaides, Luanda, Grazette, Susan, Saidman, Marc, Semigran, Thomas, Disalvo, Joren, Madsen, G William, Dec, Antonio R, Perez-Atayde, A Bernard, Collins   +9 more
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Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

The Journal of Immunology, 1988
Abstract The C4d.1 antigenic specificity was first defined serologically in 1959 as an H-2-associated cellular alloantigen first designated "G," later H-2.7. It was subsequently shown to be an allotype of component C4 of the C system, with the antigenic determinant carried on the C4d proteolytic fragment of the alpha-chain, thus the ...
P A, Taillon-Miller, D C, Shreffler
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C4d deposits mark sites of meniscal tissue disintegration

Virchows Archiv, 2006
Although the frequent occurrence of meniscal degeneration is a well-known fact and its consequences include rupture and even loss of the meniscus, the pathogenetic factors are established insufficiently. Because complement factors and leukocytes are present in synovial fluid, we tried to detect complement deposits and macrophages in menisci, which ...
Anja, Dankof, Veit, Krenn
openaire   +2 more sources

Generation and enrichment of C4d in whole serum

Journal of Immunological Methods, 1979
A comparison of two methods of generation of C4d (the degradation product of complement component C4) and a method for the preparation of an enriched serum fraction of this fragment are presented.
W H, Anderson, R M, Stroud
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C3d and C4d Deposition Early After Lung Transplantation

The Journal of Heart and Lung Transplantation, 2008
Complement staining as a predictor of antibody-mediated rejection (AMR) after lung transplantation continues to be debated.In a cohort of 33 lung transplant recipients (LTRs) we assessed early post-transplant (or=2 on more than one occasion) was observed in 20 and 11 LTRs, respectively.
Glen P, Westall, Greg I, Snell, Catriona, McLean, Tom, Kotsimbos, Trevor, Williams, Cynthia, Magro   +5 more
openaire   +2 more sources