Results 141 to 150 of about 795,908 (273)

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

Angewandte Chemie, EarlyView.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim, Jieun Kim, Juyeon Lee, Sungwoo Hong   +3 more
wiley   +2 more sources

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, EarlyView.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Bridged Pyrroloindole‐CAYC‐Gold Complexes: Harnessing Weak Secondary Intramolecular Au···H−C(sp3) Interactions in Gold(I) Catalysis

Angewandte Chemie, EarlyView.
We present a new class of electronically and sterically hindered N‐heterocyclic carbenes, referred to as bridged cyclic (amino)ylide carbene (bCAYC), where 9H‐pyrrolo[1,2‐a]indole acted as carbene core and diaryl sulfonium as ylide partner. Corresponding bCAYC‐Au(I) exhibits a weak secondary intramolecular Au···H−C(sp3) interaction as a secondary ...
Sourav Sekhar Bera, Anurag Kumar, Pengcheng Gao, Sanghamitra Das, Roger Lalancette, Roman Szostak, Michal Szostak   +6 more
wiley   +2 more sources

Neuropathic Pain and Enlarged Nerves in Adult Noonan Syndrome and Noonan Syndrome With Multiple Lentigines: Health‐Related Quality of Life and Neurologic Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) and the clinically related Noonan syndrome with multiple lentigines (NSML) belong to the group of RASopathies. Although pain is not mentioned as a characteristic feature, it has recently been reported as a clinically significant problem.
Jos M. T. Draaisma, Wesley Reintjes, Erika Leenders, Fieke Draaisma, Melanie Burgers, Lotte Kleimeier, Marco Tartaglia, Merel Klaassens, Ruud Becks, Steven Renes, Ellen Wingbermühle, Nicol C. Voermans, Nens van Alfen   +12 more
wiley   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, EarlyView.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat

Physiological Reports
Ischemia‐reperfusion injury (IRI) is the central contributing factor to acute kidney injury (AKI). Kidney tissue that becomes necrotic during this process releases a variety of pro‐inflammatory factors, driving activation of the complement cascade ...
Madison McGraw, Amod Sharma, Dinesh Bhattarai, Neelam Joshi, Neriman Gokden, Seong‐Ok Lee, Gopinath Venugopal, Nirmala Parajuli   +7 more
doaj   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Predicting Unilateral Postlaminectomy C5 Palsy by Measuring C5 Exit Foramen Area on Preoperative Computed Tomography

Iranian Journal of Neurosurgery, 2019
Background and aim: Postoperative C5 motor palsy is known as a common complication, not only after cervical laminectomy but also after anterior discectomy.
Seyed Sina Ahmadi Abhari, Masoud Khadivi, Mohammad Reza Golbakhsh, Mersad Mossavi   +3 more
doaj  

Bis(silylene)‐Mediated N═N Bond Scission of Diazo Compounds

Angewandte Chemie, EarlyView.
The carborane‐based bis(silylene) enables unprecedented N═N bond scission in diazodiarylmethanes. While xanthene‐ and aniline‐based scaffolds promote end‐on addition with partial N═N activation, the carborane‐based variant uniquely achieves complete N═N bond scission of Ar2C═N═N compounds, resulting in isolable disilicon nitride imino species.
Yun Xiong, Shenglai Yao, Matthias Driess
wiley   +2 more sources

Ion‐Lock Storage With Multi‐Logic Circuitry Gated by Polar–Dipolar Interactions in Poly(Ionic Liquids)

Angewandte Chemie, EarlyView.
Precise building block design of poly(ionic liquids) creates an opportunity to achieve ionic conductivity, energy storage, and multi‐value logic in one material while eliminating elaborate fabrication processes. ABSTRACT In these studies, we developed a new generation of polymeric materials capable of electrical energy storage and forming higher‐than ...
Sourav Biswas, Jiahui Liu, Jack Austin, Marek W. Urban   +3 more
wiley   +2 more sources