Results 161 to 170 of about 256,837 (255)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Intramolecular Nickel‐Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles

Angewandte Chemie, EarlyView.
The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner   +3 more
wiley   +2 more sources

l-Talitol. [PDF]

IUCrdata
Takashita T, Horii Y, Miyoshi S, Ishii T.   +3 more
europepmc   +1 more source

Atroposelective Pd(0)‐Catalyzed Direct Intermolecular C─H Arylation of Thiazole N‐Oxides Provides Access to Heterobiaryls

Angewandte Chemie, EarlyView.
An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley   +2 more sources

Cervical Radiculopathy Caused by Epidural Venous Varix Associated with a Dural Arteriovenous Fistula in the Anterior Condylar Confluence: A Case Report. [PDF]

J Neuroendovasc Ther
Fukunaga T, Toyota S, Murakami T, Matsumoto H, Nakashima K, Nakamura M, Yamada S, Takano K, Kobayashi M, Kishima H.   +9 more
europepmc   +1 more source

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. [PDF]

Orthop Rev (Pavia)
Counts PR, Baer TM, Viswanath O, Ganti L.   +3 more
europepmc   +1 more source

Rheological Performance of Wholemeal Flour from Bread Wheat Under Contrasting Agro-Ecological Conditions: A Multi-Environment Analysis of Mixolab^® 2 Parameters and Genotypic Stability. [PDF]

Foods
El Bouzidi H, Taghouti M, Baidani A, Gaboun F, Tadesse DW, Britel I, Moussa Hassane M, Abdellaoui MA, El Ftouh I, Oudrhiri FE, Diria G.   +10 more
europepmc   +1 more source

Entdeckung der cyclischen Form des MRT‐pH‐Sensors Z‐OMPD ermöglicht >5% 13C‐Hyperpolarisation durch SABRE

Angewandte Chemie, EarlyView.
Mit „c‐OMPD“ entdeckten wir eine bislang unbekannte fünfgliedrige Lactolstruktur, die durch Homoaldolkondensation des zentralen Metaboliten Brenztraubensäure entsteht. Wir zeigen, dass das Cyclisierungsgleichgewicht für die Funktion von OMPD als MRT‐basierte pH‐Sonde von entscheidender Bedeutung ist, und erreichen erstmals eine 13C‐Polarisation von >5 %
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Heritable transgenic schistosomes as a living platform for SARS-CoV-2 neutralizing antibody secretion. [PDF]

Nat Commun
Ittiprasert W, Smout MJ, Mann VH, Moyle M, Kinahan SM, Ackerman DN, Rivera DN, Santarpia JL, Carnes EC, Mentink-Kane MM, Costa MR, Hokke CH, Roestenberg M, Bottazzi ME, Bracken BK, Rosa BA, Djuranovic S, Pickering DA, Giacomin PR, Watterson D, Modhiran N, Moescheid MF, Grevelding CG, Mitreva M, Loukas A, Brindley PJ.   +25 more
europepmc   +1 more source

C5 Deficiency [PDF]

, 2020
openaire   +1 more source