Results 1 to 10 of about 424,323 (243)

Complement C3 and C5 deficiency affects fracture healing. [PDF]

PLoS ONE, 2013
There is increasing evidence that complement may play a role in bone development. Our previous studies demonstrated that the key complement receptor C5aR was strongly expressed in the fracture callus not only by immune cells but also by bone cells and ...
Christian Ehrnthaller, Markus Huber-Lang, Per Nilsson, Ronny Bindl, Simon Redeker, Stefan Recknagel, Anna Rapp, Tom Mollnes, Michael Amling, Florian Gebhard, Anita Ignatius   +10 more
doaj   +5 more sources

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.

PLoS ONE, 2020
Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but the
Adrianna Latuszek, Yashu Liu, Olav Olsen, Randi Foster, Marc Cao, Irena Lovric, Ming Yuan, Nina Liu, Henry Chen, Qian Zhang, Hui Xiao, Carola Springer, George Ehrlich, Vishal Kamat, Ashique Rafique, Ying Hu, Pamela Krueger, Tammy Huang, William Poueymirou, Robert Babb, Michael P Rosconi, Marc W Retter, Gang Chen, Lori Morton, Brian Zambrowicz, Jingtai Cao, Carmelo Romano, William C Olson   +27 more
doaj   +2 more sources

Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis

Molecular Therapy: Nucleic Acids, 2023
Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders.
Yoshikazu Kuboi, Yuta Suzuki, Sotaro Motoi, Chiyuki Matsui, Naoki Toritsuka, Tomoya Nakatani, Kazuhiro Tahara, Yoshinori Takahashi, Yoko Ida, Ayaka Tomimatsu, Motohiro Soejima, Toshio Imai   +11 more
doaj   +1 more source

Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis

Frontiers in Immunology, 2022
PurposeSynovial inflammation in knee osteoarthritis (OA) causes disorganized synovial angiogenesis and complement activation in synovial fluid, but links between complement and synovial microvascular pathology have not been established.
Emily U. Sodhi, Holly T. Philpott, Holly T. Philpott, McKenzie M. Carter, McKenzie M. Carter, Trevor B. Birmingham, Trevor B. Birmingham, C. Thomas Appleton, C. Thomas Appleton, C. Thomas Appleton, C. Thomas Appleton   +10 more
doaj   +1 more source

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Cells, 2023
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner   +6 more
doaj   +1 more source

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation

Frontiers in Immunology, 2023
IntroductionThe complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases.
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo   +14 more
doaj   +1 more source

Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy

Biomedicines, 2022
The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino, Fiammetta Vanoli, Rita Frangiamore, Marta Ballardini, Letizia Scandiffio, Federica Bortone, Francesca Andreetta, Fulvio Baggi, Pia Bernasconi, Carlo Antozzi, Paola Cavalcante, Renato Mantegazza   +11 more
doaj   +1 more source

Recurrent hemolytic uremic syndrome caused by gene mutation: a case report [PDF]

Childhood Kidney Diseases, 2022
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury without any association with preceding diarrhea.
Baek Sup Shin, Yo Han Ahn, Hee Gyung Kang   +2 more
doaj   +1 more source

Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines

Toxins, 2020
Enterohemorrhagic Escherichia coli (EHEC) infections can cause EHEC-associated hemolytic uremic syndrome (eHUS) via its main virulent factor, Shiga toxins (Stxs). Complement has been reported to be involved in the progression of eHUS.
Sára Kellnerová, Sneha Chatterjee, Rafael Bayarri-Olmos, Louise Justesen, Heribert Talasz, Wilfried Posch, Samyr Kenno, Peter Garred, Dorothea Orth-Höller, Marco Grasse, Reinhard Würzner   +10 more
doaj   +1 more source

Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model

Neurotrauma Reports, 2023
A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade in neurobehavioral outcomes and neuropathology after ...
Min Chen, Stephen R. Edwards, Dhiraj Maskey, Trent M. Woodruff, Stephen Tomlinson, David Reutens   +5 more
doaj   +1 more source