Results 21 to 30 of about 424,323 (243)
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically [PDF]
, 2021 Background
Complement activation plays an important pathogenic role in numerous diseases. The ratio between an activation product and its parent protein is suggested to be more sensitive to detect complement activation than the activation product itself.Nakstad, Espen Rostrup, Bosnes, Vidar, Pischke, Soeren, Andersen, Geir Øystein, Thomas, Anub Mathew, Barratt-Due, Andreas, Chaban, Viktoriia, Orrem, Hilde Lang, Sunde, Kjetil, Lundqvist, Christofer, Seljeflot, Ingebjørg, Schjalm, Camilla, Mollnes, Tom Eirik +12 morecore +2 more sourcesComplement C5 Mediates Experimental Tubulointerstitial Fibrosis [PDF]
Journal of the American Society of Nephrology, 2007 Renal fibrosis is the final common pathway of most progressive renal diseases. C5 was recently identified as a risk factor for liver fibrosis. This study investigated the role of C5 in the development of renal tubulointerstitial fibrosis by (1) induction of renal fibrosis in wild-type and C5(-/-) mice by unilateral ureteral ligation (UUO) and (2 ...Peter, Boor, Andrzej, Konieczny, Luigi, Villa, Anna-Lisa, Schult, Eva, Bücher, Song, Rong, Uta, Kunter, Claudia R C, van Roeyen, Thomas, Polakowski, Heiko, Hawlisch, Sonja, Hillebrandt, Frank, Lammert, Frank, Eitner, Jürgen, Floege, Tammo, Ostendorf +14 moreopenaire +3 more sourcesComplement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied.Jiro Kusakabe, Koichiro Hata, Hidetaka Miyauchi, Tetsuya Tajima, Yi Wang, Ichiro Tamaki, Junya Kawasoe, Yusuke Okamura, Xiangdong Zhao, Tatsuya Okamoto, Tatsuaki Tsuruyama, Shinji Uemoto +11 moredoaj +1 more sourceBorrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]
, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426) +24 morecore +1 more sourceInvestigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis
Molecular Therapy: Methods & Clinical Development, 2019 Complement-mediated damage to the neuromuscular junction (NMJ) is a key mechanism of pathology in myasthenia gravis (MG), and therapeutics inhibiting complement have shown evidence of efficacy in the treatment of MG.Linda L. Kusner, Kristina Yucius, Manjistha Sengupta, Andrew G. Sprague, Dhruv Desai, Tuyen Nguyen, Klaus Charisse, Satya Kuchimanchi, Rajeev Kallanthottathil, Kevin Fitzgerald, Henry J. Kaminski, Anna Borodovsky +11 moredoaj +1 more sourceIn vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway
Frontiers in Immunology, 2023 IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3.Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Marc Schmid, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke +12 moredoaj +1 more sourceContribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson +14 morecore +1 more sourceFunctional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models
Frontiers in Immunology, 2018 Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham +8 moredoaj +1 more sourceComplement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi [PDF]
, 2010 Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard +34 morecore +2 more sourcesComplement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage [PDF]
, 2020 Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it ...Brouwer, Matthijs, Rinkel, G. J. E., Meijers, Joost C. M., van Dijk, Bart J., Kloek, Anne T., van der Kamp, Marije J., van de Beek, Diederik, Knaup, V. L., Osuka, Koji, Hol, Elly M., Vergouwen, Mervyn D I, van de Beek, D., Morgan, B. Paul, Kloek, Anne T, Ruigrok, Ynte M., Meijers, Joost C.M., Rinkel, Gabriel J. E., Morgan, B. P., Meijers, J. C. M., Hol, E. M., Vergouwen, M. D. I., Rinkel, Gabriel J.E., van der Kamp, Marije J, Pekna, Marcela, van Dijk, B. J., Knaup, Veronique L, Vergouwen, Mervyn D. I., Aronica, E., Aronica, Eleonora, Vergouwen, Mervyn D.I., van der Kamp, M. J., Ruigrok, Ynte M, Pekna, Marcela,, van Dijk, Bart J, Kloek, A. T., Brouwer, M., Morgan, B Paul, Rinkel, Gabriel J E, Hol, Elly M, Meijers, Joost C M, Osuka, K., Knaup, Veronique L., Ruigrok, Y. M. +42 morecore +1 more source
