Results 41 to 50 of about 39,430 (282)

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.

PLoS ONE, 2018
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these disorders can be effectively treated with an antibody that inhibits complement C5, the high plasma ...
Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu   +15 more
doaj   +1 more source

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj   +1 more source

Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk

Translational Psychiatry, 2023
Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis.
TianHong Zhang, JiaHui Zeng, JiaYi Ye, YuQing Gao, YeGang Hu, LiHua Xu, YanYan Wei, XiaoChen Tang, HaiChun Liu, Tao Chen, ChunBo Li, ChunLing Wan, JiJun Wang   +12 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source

Complement component C5 is not involved in scrapie pathogenesis

Immunobiology, 2004
During transmissible spongiform encephalopathy (TSE) infections the accumulation of abnormal prion protein within the brain is often accompanied by severe neurodegeneration. Studies have implicated complement, including the membrane attack complex (MAC, C5b-C9), in inducing pathology in some neurodegenerative diseases.
Neil A, Mabbott, Moira E, Bruce
openaire   +2 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi

, 2010
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.
Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard   +34 more
core   +1 more source

Functional Role of the Noncatalytic Subunit of Complement C5 Convertase [PDF]

The Journal of Immunology, 2000
Abstract The C5 convertase is a serine protease that consists of two subunits: a catalytic subunit which is bound in a Mg2+-dependent complex to a noncatalytic subunit. To understand the functional role of the noncatalytic subunit, we have determined the C5-cleaving properties of the cobra venom factor-dependent C5 convertase (CVF,Bb)
N, Rawal, M K, Pangburn
openaire   +2 more sources

Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.

PLoS ONE, 2018
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation ...
Robin Babadjouni, Arati Patel, Qinghai Liu, Kristina Shkirkova, Krista Lamorie-Foote, Michelle Connor, Drew M Hodis, Hank Cheng, Constantinos Sioutas, Todd E Morgan, Caleb E Finch, William J Mack   +11 more
doaj   +1 more source

Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury

Renal Failure, 2019
Aim: The complement system is activated in acute kidney injury (AKI). Anti-C5 antibody targets the common terminal portion of the complement cascade that generate the terminal complex C5b-9 and has a renal-protective effect in paroxysmal nocturnal ...
Shani Zilberman-Itskovich, Ramzia Abu-Hamad, Moshe Stark, Shai Efrati   +3 more
doaj   +1 more source

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice

Respiratory Research, 2006
Background Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production.
Siddiqui Javed, Bolgos Gerald L, Kim Jiyoun, McKinley Laura, Remick Daniel G   +4 more
doaj   +1 more source