Results 41 to 50 of about 424,323 (243)
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.
PLoS ONE, 2018 Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation ...
Robin Babadjouni +11 more
doaj +1 more source
Complement component C5 is not involved in scrapie pathogenesis
Immunobiology, 2004 During transmissible spongiform encephalopathy (TSE) infections the accumulation of abnormal prion protein within the brain is often accompanied by severe neurodegeneration. Studies have implicated complement, including the membrane attack complex (MAC, C5b-C9), in inducing pathology in some neurodegenerative diseases.
Neil A, Mabbott, Moira E, Bruce
openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice
Scientific Reports, 2021 The complement system plays a role in the formation of sub-retinal pigment epithelial (RPE) deposits in early stages of age-related macular degeneration (AMD).
Donita L. Garland +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice
Respiratory Research, 2006 Background Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production.
Siddiqui Javed +4 more
doaj +1 more source
Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies [PDF]
, 2023 The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases.
de Haas, Carla J C +12 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury
Renal Failure, 2019 Aim: The complement system is activated in acute kidney injury (AKI). Anti-C5 antibody targets the common terminal portion of the complement cascade that generate the terminal complex C5b-9 and has a renal-protective effect in paroxysmal nocturnal ...
Shani Zilberman-Itskovich +3 more
doaj +1 more source
Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
Frontiers in Immunology, 2020 Better understanding of roles of complement in pathology has fuelled an explosion of interest in complement-targeted therapeutics. The C5-blocking monoclonal antibody (mAb) eculizumab, the first of the new wave of complement blocking drugs, was FDA ...
Wioleta M. Zelek, B. Paul Morgan
doaj +1 more source