Results 31 to 40 of about 424,323 (243)

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. [PDF]

PLoS ONE, 2013
The C5 complement protein is a potent inflammatory mediator that has been implicated in the pathogenesis of both stroke and neurodegenerative disease. Microvascular failure is proposed as a potential mechanism of injury.
Qinghai Liu, Shuhan He, Leonid Groysman, David Shaked, Jonathan Russin, Thomas C Scotton, Steven Cen, William J Mack   +7 more
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates.

PLoS ONE, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by uncontrolled complement activation; effective and approved treatments include terminal complement inhibition.
Kishor Devalaraja-Narashimha, Cong Huang, Marc Cao, Ya Ping Chen, Anna Borodovsky, William C Olson, Lori G Morton, Marc W Retter   +7 more
doaj   +2 more sources

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention. [PDF]

PLoS ONE, 2018
The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been ...
Nehemiah Zewde, Dimitrios Morikis
doaj   +1 more source

Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs [PDF]

, 2022
Introduction: Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood.
Nilsen, Bent Aksel, Ludviksen, Judith K, Christiansen, Dorte, Landsem, Anne, Mollnes, Tom Eirik, Fure, Hilde, Dybwik, Knut Gustav, Storm, Benjamin, Braaten, Tonje, Nielsen, Erik Waage, Pettersen, Kristin   +10 more
core   +1 more source

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.

PLoS ONE, 2018
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these disorders can be effectively treated with an antibody that inhibits complement C5, the high plasma ...
Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu   +15 more
doaj   +1 more source

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj   +1 more source

A fusion protein of the two tick-derived C5 inhibitors OmCI and RaCI: complete C5 inhibition despite strong complement activation

Immunobiology
The complement system must be tightly regulated to prevent tissue damage and disease, yet current C5 inhibitors like the anti-C5 monoclonal antibody Eculizumab – though clinically approved ( e.g. , for paroxysmal nocturnal haemoglobinuria, PNH) - fail to
Sümeyye Erdemci-Evin, Verena Kaupper, Jannik Sichau, Elsa Dopler, Hiba Ghaboosh, Arthur Dopler, Christoph Q. Schmidt   +6 more
doaj   +1 more source

Complement-Mediated Virus Infectivity Neutralisation by HLA Antibodies Is Associated with Sterilising Immunity to SIV Challenge in the Macaque Model for HIV/AIDS. [PDF]

, 2014
Sterilising immunity is a desired outcome for vaccination against human immunodeficiency virus (HIV) and has been observed in the macaque model using inactivated simian immunodeficiency virus (SIV).
Mark Robinson, Hassall, M, Stott James, Quartey-Papafio, R, Martin Cranage, Cranage, M, Page Mark, James Stott, Robinson Mark, Mark Hassall, Mark Page, Robinson, M, Quartey-Papafio Ruby, Page, M, Neil Almond, Hassall Mark, Almond, N, Almond Neil, Ruby Quartey-Papafio, Cranage Martin, Stott, J   +20 more
core   +1 more source

Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk

Translational Psychiatry, 2023
Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis.
TianHong Zhang, JiaHui Zeng, JiaYi Ye, YuQing Gao, YeGang Hu, LiHua Xu, YanYan Wei, XiaoChen Tang, HaiChun Liu, Tao Chen, ChunBo Li, ChunLing Wan, JiJun Wang   +12 more
doaj   +1 more source