Results 51 to 60 of about 39,430 (282)

Experimental Characterization of Mycelium‐Based Composites Under Multiple Loading Conditions

Advanced Engineering Materials, EarlyView.
This study examines the mechanical response of mycelium‐based composites under compression, shear, and tension using mechanical testing and imaging methods. The comparison between unpressed and hot‐pressed specimens shows that hot pressing is associated with higher compression and shear stiffnesses.
Shaghayegh Elahi, Kimiya Tajik, Harvey Shaw, Matti Isakov, Sami Pajunen, Lauri Rautkari   +5 more
wiley   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. [PDF]

, 2001
Components of innate immunity have recently been implicated in the regulation of developmental processes. Most strikingly,complement factors appear to be involved in limb regeneration in certain urodele species.
MASTELLOS, D, LAMBRIS, J. D., PAPADIMITRIOU, J. C, TSONIS, P. A, FRANCHINI, Silvia   +4 more
core   +1 more source

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species

Frontiers in Immunology, 2020
Better understanding of roles of complement in pathology has fuelled an explosion of interest in complement-targeted therapeutics. The C5-blocking monoclonal antibody (mAb) eculizumab, the first of the new wave of complement blocking drugs, was FDA ...
Wioleta M. Zelek, B. Paul Morgan
doaj   +1 more source

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies [PDF]

, 2023
The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases.
de Haas, Carla J C, van Oosterom, Fleur, van Keulen, Joanne E, Heukers, Raimond, Heesterbeek, Dani A C, Struijf, Eva M, Gros, Piet, Ruyken, Maartje, Rooijakkers, Suzan H M, Bardoel, Bart W, Siere, Danique Y, Dolk, Edward, De la O Becerra, Karla I   +12 more
core  

A Versatile Microfluidic Extrusion‐Based Hydrogel Platform for Self‐Organization and Long‐Term Maintenance of Engineered 3D Lymphatic Endothelium

Advanced Healthcare Materials, EarlyView.
Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi, Adeline Boyreau, Laura Chaillot, Wilfried Souleyreau, Laetitia Andrique, Pierre‐Olivier Guichet, Thomas Mathivet, Andreas Bikfalvi, Pierre Nassoy   +8 more
wiley   +1 more source

Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices

Frontiers in Immunology, 2021
Complement activation is key to anti-microbial defenses by directly acting on microbes and indirectly by triggering cellular immune responses. Complement activation may also contribute to the pathogenesis of numerous inflammatory and immunological ...
Sinan Muldur, Sinan Muldur, Douangsone D. Vadysirisack, Sharan Ragunathan, Yalan Tang, Alonso Ricardo, Camil Elie Sayegh, Daniel Irimia, Daniel Irimia   +8 more
doaj   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

Biomedicines, 2022
Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of ...
Sarah Julien, Douangsone Vadysirisack, Camil Sayegh, Sharan Ragunathan, Yalan Tang, Emma Briand, Marion Carrette, Laetitia Jean, Rachid Zoubairi, Henri Gondé, Olivier Benveniste, Yves Allenbach, Laurent Drouot, Olivier Boyer   +13 more
doaj   +1 more source

Complement factor C5 in Atlantic salmon (Salmo salar): characterization of cDNA, protein and glycosylation [PDF]

, 2019
Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates. We report the characterization of C5 cDNA and protein from Atlantic salmon (Salmo salar), a teleost fish species of high importance in aquaculture ...
Johansen, Wenche, Moen, Anders, Agusti-Ridaura, Celia, Grove, Søren, Anonsen, Jan Haug, Strætkvern, Knut Olav, Azar, Amir Sefidmouy   +6 more
core   +1 more source