Results 71 to 80 of about 39,430 (282)

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Targeted Delivery of Neutralizing Anti-C5 Antibody to Renal Endothelium Prevents Complement-Dependent Tissue Damage

Frontiers in Immunology, 2017
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage.
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F. Di Naro, Francesco Tedesco, Paolo Macor   +10 more
doaj   +1 more source

The activation of human complement component C5 by a fluid phase C5 convertase.

Journal of Biological Chemistry, 1983
Complement component C5 is converted to C5a and C5b by the cobra venom factor-dependent C3/C5 convertase CVF,Bb (EC 3.4.21.47). The C5 convertase produces selective proteolytic cleavage of an arginyl-leucine peptide bond at positions 74-75 in the alpha chain of C5.
R G, DiScipio, C A, Smith, H J, Muller-Eberhard, T E, Hugli   +3 more
openaire   +2 more sources

Thermoelectric Gating Organic Electrochemical Transistors Enabled by Printable Ionogels With n‐p Convertible Thermopower

Advanced Science, EarlyView.
A type of thermoelectric ionogels with convertible n‐p thermopowers are demonstrated with Seebeck coefficients ranging from ‐3.61 to +9.74 mV K−1. Thus, thermoelectric gating organic electrochemical transistor is achieved by employing ionogel as thermoelectric modules and ionic dielectrics simultaneously, paving the road to self‐powered, highly ...
Xingyu Hu, Xinwen Yan, Ling Huang, Xiaohang Zhang, Xuan Cao, Cong Zhang, Qingqing Sun, Hanyu Jia, Xuying Liu   +8 more
wiley   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Frontiers in Immunology, 2018
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
Sidonia Mihai, Sidonia Mihai, Misa Hirose, Yi Wang, Joshua M. Thurman, V. Michael Holers, B. Paul Morgan, Jörg Köhl, Jörg Köhl, Detlef Zillikens, Ralf J. Ludwig, Falk Nimmerjahn   +11 more
doaj   +1 more source

Case Report: Tackling Complement Hyperactivation With Eculizumab in Atypical Hemolytic Uremic Syndrome Triggered by COVID-19

Frontiers in Pharmacology, 2022
Hemolytic uremic syndrome (HUS) is a rare life-threatening disease of unrestrained complement system dysregulation, microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure in genetically predisposed individuals.
Valentina Fanny Leone, Amantia Imeraj, Sara Gastoldi, Caterina Mele, Lucia Liguori, Carmelita Condemi, Piero Ruggenenti, Giuseppe Remuzzi, Camillo Carrara   +8 more
doaj   +1 more source

Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses [PDF]

, 2017
Contains fulltext : 177337.pdf (Publisher’s version ) (Open Access)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 ...
Heuvel, L.P.W.J. van den, Thomas, A.M., Thomas, Anub Mathew, Alice Gustavsen, Nilsson, Per, Barratt-Due, Andreas, Volokhina, E.B., van den Heuvel, Lambertus P., Elena B. Volokhina, Bergseth, Grethe, Gustavsen, A., Bergseth, G., Gustavsen, Alice, Mollnes, T.E., Barratt-Due, A., Nilsson, P.H., Nilsson, Per H., Tom E. Mollnes, Grethe Bergseth, Lambertus P. van den Heuvel, Anub Mathew Thomas, Volokhina, Elena B., Mollnes, Tom Eirik, Bergseth, Grete, Andreas Barratt-Due, Mollnes, Tom E., Per H. Nilsson   +26 more
core   +1 more source

Electrochemical Modulation of Laser‐Induced Covalent Functionalization of Graphene

Advanced Science, EarlyView.
Photoelectrochemical functionalization of graphene introduces the electrochemical potential as an additional parameter for the laser‐induced covalent modification of graphene. Tuning of the potential allows for amplification or suppression of the functionalization reaction with constant laser parameters, which enables in situ Raman analysis of ...
Tamara Nagel, Linda Feuerstein, Kevin Gerein, Stefan Wolff, Janina Maultzsch, Andreas Hirsch, Inez M. Weidinger, Frank Hauke   +7 more
wiley   +1 more source

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, EarlyView.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources