Results 71 to 80 of about 424,323 (243)

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Frontiers in Immunology, 2018
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
Sidonia Mihai, Sidonia Mihai, Misa Hirose, Yi Wang, Joshua M. Thurman, V. Michael Holers, B. Paul Morgan, Jörg Köhl, Jörg Köhl, Detlef Zillikens, Ralf J. Ludwig, Falk Nimmerjahn   +11 more
doaj   +1 more source

Effects of Complement C5 on Apoptosis in Experimental Autoimmune Encephalomyelitis [PDF]

The Journal of Immunology, 2004
Abstract Complement activation is involved in the initiation of Ab-mediated inflammatory demyelination in experimental autoimmune encephalomyelitis (EAE). At a sublytic dose, the C5b-9 membrane attack complex protects oligodendrocytes (OLG) from apoptosis.
Teodora, Niculescu, Susanna, Weerth, Florin, Niculescu, Cornelia, Cudrici, Violeta, Rus, Cedric S, Raine, Moon L, Shin, Horea, Rus   +7 more
openaire   +2 more sources

Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]

, 2005
Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aubin, K., Williams, I., Jones, N.A., Borrow, P., Holuigue, S., Cornforth, D., Wong, M., Pellegrino, P., McKnight, A., Aasa-Chapman, M.M.I., Newton, P.   +10 more
core  

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Complement C5 Inhibitor Ameliorates a Case of Dysferlinopathy

Neurology Neuroimmunology & Neuroinflammation
Dysferlinopathy is an autosomal recessive muscular dystrophy caused by pathogenic variants of the DYSF gene. Currently, no clinical effective treatment is available. Given the myopathologic and animal model evidence on complement activation in dysferlinopathy, we explored the potential therapeutic effect of complement inhibition.We reported a case of ...
Shuaikun Kang, Qingqing Wang, He Lv, Jianwen Deng, Wei Zhang, Xin Lu, Yun Yuan, Zhaoxia Wang, Fuze Zheng, Meng Yu   +9 more
openaire   +2 more sources

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

, 2017
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in certain complement-mediated diseases.
Christoph Q. Schmidt, Lambris, John D., Inge von Zabern, Höchsmann, Britta, Nadine Kuhn, Christof Weinstock, Weinstock, Christof, Markus J. Harder, Skerra, Arne, Arne Skerra, John D. Lambris, Thomas Simmet, Anliker, Markus, Daniel Ricklin, Schmidt, Christoph Q., Schrezenmeier, Hubert, Hubert Schrezenmeier, Markus Anliker, Simmet, Thomas, Ricklin, Daniel, Britta Höchsmann, Harder, Markus J., Kuhn, Nadine, von Zabern, Inge   +23 more
core   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

The activation of human complement component C5 by a fluid phase C5 convertase.

Journal of Biological Chemistry, 1983
Complement component C5 is converted to C5a and C5b by the cobra venom factor-dependent C3/C5 convertase CVF,Bb (EC 3.4.21.47). The C5 convertase produces selective proteolytic cleavage of an arginyl-leucine peptide bond at positions 74-75 in the alpha chain of C5.
R G, DiScipio, C A, Smith, H J, Muller-Eberhard, T E, Hugli   +3 more
openaire   +2 more sources

Inhibitors of C5 complement enhance vaccinia virus oncolysis [PDF]

Cancer Gene Therapy, 2013
Genetically engineered tumor-selective vaccinia virus (VV) has been demonstrated to be a highly effective oncolytic agent, but immune clearance may limit its therapeutic potential. As previously demonstrated, immunosuppression can lead to significant enhancement of viral recovery and therapeutic effect, but the magnitude of complement-mediated viral ...
D, Magge, Z S, Guo, M E, O'Malley, L, Francis, R, Ravindranathan, D L, Bartlett   +5 more
openaire   +2 more sources