Results 81 to 90 of about 424,323 (243)

Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses [PDF]

, 2017
Contains fulltext : 177337.pdf (Publisher’s version ) (Open Access)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 ...
Heuvel, L.P.W.J. van den, Thomas, A.M., Thomas, Anub Mathew, Alice Gustavsen, Nilsson, Per, Barratt-Due, Andreas, Volokhina, E.B., van den Heuvel, Lambertus P., Elena B. Volokhina, Bergseth, Grethe, Gustavsen, A., Bergseth, G., Gustavsen, Alice, Mollnes, T.E., Barratt-Due, A., Nilsson, P.H., Nilsson, Per H., Tom E. Mollnes, Grethe Bergseth, Lambertus P. van den Heuvel, Anub Mathew Thomas, Volokhina, Elena B., Mollnes, Tom Eirik, Bergseth, Grete, Andreas Barratt-Due, Mollnes, Tom E., Per H. Nilsson   +26 more
core   +2 more sources

A Unified Flash Memory Platform for Mode‐Adaptive and Robust AI Computation

Advanced Science, EarlyView.
A unified AND‐type flash memory platform enables both transistor‐mode and capacitor‐mode computing‐in‐memory operations within the same device structure. By selectively switching the sensing mode through peripheral reconfiguration, the platform provides adaptable trade‐offs between computational accuracy, robustness, and energy efficiency for AI ...
Dayeon Yu, Hwiho Hwang, Byeongchan Oh, Junmo Lee, Shimeng Yu, Tae‐Hyeon Kim, Hyungjin Kim   +6 more
wiley   +1 more source

The development of atypical hemolytic uremic syndrome depends on complement C5.

, 2011
Gene variants in the alternative pathway of the complement system strongly associate with atypical hemolytic uremic syndrome (aHUS), presumably by predisposing to increased complement activation within the kidney.
Botto M, MACOR, PAOLO, TEDESCO, FRANCESCO, Rose KL, Pickering MC, de Jorge EG, Paixão Cavalcante D, Cook HT   +7 more
core   +1 more source

Rayleigh ratios and molar masses of complexes formed between TPP-2799 and complement component C5 in phosphate-buffered saline.

, 2023
(A) TPP-2799 alone (700 nM). (B) TPP-2799 (700 nM) plus complement component C5 (400 nM). (C) complement component C5 alone (400 nM). (EPS)
Josh Cone (15332831), Krista Johnson (10976806), Paul Tamburini (5095490), Yuchun Zhang (314384), Lida Kimmel (15332834), Douglas Sheridan (5095502)   +5 more
core   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats

Physiological Reports
Ischemia–reperfusion injury (IRI) is a major driver of acute kidney injury and development of chronic kidney disease. Although complement activation worsens IRI, the roles of upstream (C3) versus downstream (C5) components remain unclear.
Dinesh Bhattarai, Amod Sharma, Madison McGraw, Se‐Ran Jun, Neelam Joshi, Neriman Gokden, Samuel Mackintosh, Nirmala Parajuli   +7 more
doaj   +1 more source

The role of microglia and complement C5/C5a in the pathogenesis of rhegmatogenous retinal detachment with choroidal detachment

Computational and Structural Biotechnology Journal
Background: Rhegmatogenous retinal detachment with choroidal detachment (RRDCD) is an uncommon and sight-threatening disorder marked by fast development and significant inflammation.
Huiyan Xu, Qiuhong Wang, Xuan Chen, Qingyu Huang, Shasha Xu, Zhifeng Wu   +5 more
doaj   +1 more source

Complement C5 inhibition in early onset HELLP syndrome

Blood Advances
Gloria F. Gerber, Robert A. Brodsky, Arthur Jason Vaught   +2 more
doaj   +3 more sources

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of Klebsiella pneumoniae.

PLoS Pathogens
Membrane Attack Complex (MAC) pores are important in the human innate immune response to directly kill pathogenic Gram-negative bacteria. MAC pores assemble when complement proteins in serum are activated on bacteria and convert complement protein C5 ...
Kulsum M Dawoodbhoy, Coco R Beudeker, Panagiotis Theofilidis, Frerich M Masson, Michiel van der Flier, Suzan H M Rooijakkers, Bart W Bardoel, Dennis J Doorduijn   +7 more
doaj   +1 more source