Results 101 to 110 of about 39,430 (282)

Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat

Physiological Reports
Ischemia‐reperfusion injury (IRI) is the central contributing factor to acute kidney injury (AKI). Kidney tissue that becomes necrotic during this process releases a variety of pro‐inflammatory factors, driving activation of the complement cascade ...
Madison McGraw, Amod Sharma, Dinesh Bhattarai, Neelam Joshi, Neriman Gokden, Seong‐Ok Lee, Gopinath Venugopal, Nirmala Parajuli   +7 more
doaj   +1 more source

Conserved Surface-Exposed K/R-X-K/R Motifs and Net Positive Charge on Poxvirus Complement Control Proteins Serve as Putative Heparin Binding Sites and Contribute to Inhibition of Molecular Interactions with Human Endothelial Cells: a Novel Mechanism for Evasion of Host Defense

, 2000
Vaccinia virus complement control protein (VCP) has been shown to possess the ability to inhibit both classical and alternative complement pathway activation.
Shchelkunov, SN, Reynolds, DN, Kotwal, GJ, Justus, DE, Srisatjaluk, R, Loparev, VN, Totmenin, AV, Keeling, KL, Smith, SA, Parkinson, J, Barlow, PN, Mullin, NP   +11 more
core  

The conversion of human complement component C5 into fragment C5b by the alternative-pathway C5 convertase [PDF]

Biochemical Journal, 1981
The cleavage of human complement component C5 to fragment C5b by the alternative pathway C5 convertase was studied. The alternative-pathway C5 convertase on zymosan can be represented by the empirical formula zymosan--C3b2BbP. Both properdin-stabilized C3 and C5 convertase activities decay with a half life of 34 min correlating with the loss of the Bb ...
openaire   +2 more sources

Discordance between Free C5 and CH50 Complement Assays in Measuring Complement C5 Inhibition in Patients with aHUS Treated with Ravulizumab

Blood, 2019
Background: The 50% hemolytic complement (CH50) assay is a non-specific qualitative assay of complement function. CH50 is sometimes used in patients with complement-mediated thrombotic microangiopathy such as atypical hemolytic uremic syndrome (aHUS) to monitor response to complement inhibition.
Spero Cataland, Gema Ariceta, Peter Chen, Bradley Dixon, Katherine Garlo, Laurence Greenbaum, Eric Rondeau, Marie Scully, Stephan Ortiz   +8 more
openaire   +1 more source

Activation-dependent epitopes in the terminal complement pathway

, 1989
Assembly of the terminal complement complex (TCC) during complement activation is associated with considerable antigenic changes in the individual C5, C6, C7, C8 and C9 components. Numerous neoepitopes specific for the TCC are exposed.
Lea, T., Mollnes, T. E., Tschopp, J.
core  

EspP, a Serine Protease of Enterohemorrhagic Escherichia coli , Impairs Complement Activation by Cleaving Complement Factors C3/C3b and C5

, 2010
Hemolytic-uremic syndrome (HUS) is a life-threatening disorder characterized by hemolytic anemia, thrombocytopenia, and renal insufficiency. It is caused mainly by infections with enterohemorrhagic Escherichia coli (EHEC ...
Jens Brockmeyer, Abdul Basit Khan, Bettina Sarg, Reinhard Würzner, Silvia Ehrlenbach, Herbert Lindner, Dorothea Orth, Georg Huber, Helge Karch   +8 more
core   +1 more source

Characterising a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis [PDF]

, 2018
C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro‐inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex.
Zelek, Wioleta M., Harris, Claire L., Walters, David, Stott, Matthew, Morgan, B. Paul   +4 more
core   +1 more source

Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement.

The Journal of biological chemistry, 2008
Although the initiating complex of lectin pathway (called M1 in this study) generates C3/C5 convertases similar to those assembled by the initiating complex (C1) of the classical pathway, activation of complement component C5 via the lectin pathway has not been examined.
Nenoo, Rawal, Rema, Rajagopalan, Veena P, Salvi   +2 more
openaire   +1 more source

A Novel Role for the Fifth Component of Complement (C5) in Cardiac Physiology

PLoS ONE, 2011
We have previously demonstrated that C5-deficient A/J and recombinant congenic BcA17 mice suffer from cardiac dysfunction when infected with C. albicans blastospores intravenously. During these studies we had observed that, even in the control un-infected state, BcA17 hearts displayed alterations in gene expression that have been associated with ...
Mullick, Alaka, Tremblay, Jessy, Leon, Zully, Gros, Philippe   +3 more
openaire   +5 more sources

Asymmetric α‐Alkylation With Activated and Unactivated Electrophiles by a Highly Productive and Recyclable Lewis Acid/Imidazolium Catalyst

Angewandte Chemie International Edition, EarlyView.
An air‐stable, easily prepared, bifunctional Cu(II)/imidazolium complex enables highly enantioselective α‐alkylation of 1,3‐dicarbonyls with outstanding productivity (TON up to 1740). Highlights include broad electrophile scope spanning π‐activated and nonactivated reagents, stereo‐retentive allylation, simple catalyst synthesis, and efficient catalyst
Johanna Haußmann, Alexander Beck, Dominik Hornung, Michael Mistele, Alexander Allgaier, Wolfgang Frey, Joris van Slageren, Johannes Kästner, René Peters   +8 more
wiley   +1 more source