Results 111 to 120 of about 39,430 (282)

Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

Journal of Immunology Research, 2019
Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are ...
Lorena Bavia, Íris A. de Castro, Mariane Tami Amano, Ana Maria Gonçalves da Silva, Silvio Arruda Vasconcellos, Lourdes Isaac   +5 more
doaj   +1 more source

Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection

, 2005
Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aubin, K., Williams, I., Jones, N.A., Borrow, P., Holuigue, S., Cornforth, D., Wong, M., Pellegrino, P., McKnight, A., Aasa-Chapman, M.M.I., Newton, P.   +10 more
core  

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source

Validation of the ABL + DT model: An ecosystemic framework for integrating arts and digital technologies in primary education

British Educational Research Journal, EarlyView.
Abstract Primary education teachers face increasing challenges in engaging diverse learners and fostering creativity, digital competence and other transversal skills, often lacking clear, practical guidance for integrating these skills into their classrooms.
Nella Escala, Montse Guitert, Teresa Romeu   +2 more
wiley   +1 more source

Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances

Frontiers in Pharmacology
Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of hematopoietic stem cell transplantation in which systemic complement activation induces endothelial injury, leading to microangiopathic hemolytic anemia ...
Taichiro Tokura, Taichiro Tokura, Sayuri Motomura   +2 more
doaj   +1 more source

Requirement of activation of complement C3 and C5 for antiphospholipid antibody–mediated thrombophilia

, 2005
Objective:Antiphospholipid antibodies (aPL) have been shown to induce thrombosis, activate endothelial cells, and induce fetal loss. The pathogenesis of aPL-induced thrombosis, although not completely understood, may involve platelet and endothelial cell
Liu, Xiaowei, Jane Salmon, Mariano Vega‐Ostertag, Espinola, Ricardo G, Vega-Ostertag, Mariano, Guillermina Girardi, Xiaowei Liu, Pierangeli, Silvia S, Salmon, Jane, Girardi, Guillermina, Silvia S. Pierangeli, Ricardo G. Espinola   +11 more
core   +1 more source

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Direct Switch From Iptacopan to Pegcetacoplan in a Patient With Paroxysmal Nocturnal Hemoglobinuria

eJHaem
Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematologic disorder treated with complement inhibitors. Currently, patients with suboptimal response to C5 inhibitors may be switched to proximal complement inhibitors, such as ...
Vitalii Latyshev, Zalina Fidarova, Elena Lukina, Elena Parovichnikova   +3 more
doaj   +1 more source

Complement C5 inhibition attenuates lung inflammation in H1N1 influenza

, 2010
Background: Viral infection including pandemic influenza may be associated with severe acute respiratory distress syndrome (ARDS) characterised by rapidly developing alveolitis with dense neutrophil infiltration.
Nunn, Miles, Ryffel, Bernhard, Garcia, Cristiana C., Weston-Davies, Wynne, Miles Nunn, Wynne Weston-Davies, Cristiana C. Garcia, Russo, Remo C., Remo C. Russo, Mauro M. Teixeira, Luciana P. Tavares, Teixeira, Mauro M., Tavares, Luciana P., Bernhard Ryffel   +13 more
core   +1 more source