Results 11 to 20 of about 39,430 (282)
Structural basis for therapeutic inhibition of complement C5. [PDF]
Nat Struct Mol Biol, 2016 Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However,
Jore MM +7 more
europepmc +6 more sources
An inhibitor of complement C5 provides structural insights into activation. [PDF]
Proc Natl Acad Sci U S A, 2020 The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation.
Reichhardt MP +8 more
europepmc +8 more sources
Plasmin as a complement C5 convertase [PDF]
EBioMedicine, 2016 Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
Lawrence L. Leung, John Morser
doaj +5 more sources
Complement C5 inhibition in early onset HELLP syndrome [PDF]
Blood AdvancesGloria F. Gerber +2 more
doaj +4 more sources
Complement C5 protein as a marker of subclinical atherosclerosis [PDF]
Journal of the American College of Cardiology, 2020 16 p.-5 fig.-3 tab.-1 il. cent.BACKGROUND: The mechanisms underlying early atherosclerotic plaque formation are not completely understood. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking.OBJECTIVES: The purpose of this study was to
Vázquez, Jesús +19 more
core +7 more sources
, 2012 Complement C5 is a 189 kDa protein synthesized in liver as a single-chain precursor molecule. The precursor molecule is then cleaved to a disulfide linked two-chain glycoprotein consisting of a 115 kDa (C5α) and a 75 kDa N-terminal (C5β) chain.
Dinasarapu, Ashok Reddy +3 more
core +2 more sources
Complement factors C1q, C3 and C5 in brain and serum of mice with cerebral malaria [PDF]
Malaria Journal, 2008 Background The patho-mechanisms leading to brain damage due to cerebral malaria (CM) are yet not fully understood. Immune-mediated and ischaemic mechanisms have been implicated.
Helbok Raimund +7 more
doaj +2 more sources
Scientific Reports, 2017 Dysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) and ...
Taku Fukuzawa +33 more
doaj +2 more sources
Using genetics to explore complement C5 as a druggable protein in periodontitis. [PDF]
Front ImmunolAimAn excessively activated or dysregulated complement system has been proven to be a vital contributor to the pathogenesis of periodontitis. It has been previously hypothesized that inhibiting the activity of complement component C5 by targeting the C5a
Alayash Z +7 more
europepmc +2 more sources
Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies [PDF]
Blood Advances, 2018 : The complement and coagulation cascades interact at multiple levels in thrombosis and inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet and tissue factor (TF) procoagulant activation dependent on protein ...
Nadine Müller-Calleja +5 more
doaj +2 more sources