Results 11 to 20 of about 424,323 (243)
The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria [PDF]
Blood, 2020 Abstract Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete suppression of the terminal complement pathway and the high serum concentration of C5 pose challenges to drug development that result in IV-only treatment ...
Régis Peffault de Latour +27 more
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Complement C5 Protein as a Marker of Subclinical Atherosclerosis [PDF]
Journal of the American College of Cardiology, 2020 The mechanisms underlying early atherosclerotic plaque formation are not completely understood. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking.The purpose of this study was to analyze the temporal and topologically resolved protein changes taking place in human aortas with early atherosclerosis to find new potential diagnostic ...
Martínez-López, Diego +17 more
openaire +6 more sources
, 2012 Complement C5 is a 189 kDa protein synthesized in liver as a single-chain precursor molecule. The precursor molecule is then cleaved to a disulfide linked two-chain glycoprotein consisting of a 115 kDa (C5α) and a 75 kDa N-terminal (C5β) chain. C5 is present in all the three known complement activation pathways: classical, alternative and lectin.
Chandrasekhar, Anjana +3 more
core +3 more sources
The allosteric modulation of Complement C5 by knob domain peptides [PDF]
eLife, 2020 To overcome limited germline combinatorial diversity, bovines have evolved a subset of antibodies with ultra-long CDRH3 regions that harbour cysteine-rich knob domains. To produce affinity-maturated peptides, we previously isolated autonomous 3-6 kDa knob domains from bovine antibodies.
Alex Macpherson +17 more
openaire +9 more sources
Structural basis for therapeutic inhibition of complement C5 [PDF]
Nature Structural & Molecular Biology, 2016 Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However, the mechanism of C5 activation by C5 convertases remains elusive, thus limiting development of ...
Matthijs M Jore +7 more
openaire +5 more sources
Scientific Reports, 2017 Dysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) and ...
Taku Fukuzawa +33 more
doaj +2 more sources
Complement factors C1q, C3 and C5 in brain and serum of mice with cerebral malaria [PDF]
Malaria Journal, 2008 Background The patho-mechanisms leading to brain damage due to cerebral malaria (CM) are yet not fully understood. Immune-mediated and ischaemic mechanisms have been implicated.
Helbok Raimund +7 more
doaj +2 more sources
Plasmin as a complement C5 convertase [PDF]
EBioMedicine, 2016 Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
Lawrence L. Leung, John Morser
doaj +3 more sources
An inhibitor of complement C5 provides structural insights into activation [PDF]
Proceedings of the National Academy of Sciences, 2019 The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick
Reichhardt, M +8 more
openaire +7 more sources
The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
core +1 more source