Results 161 to 170 of about 6,241 (216)
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Abstract C52: Enhancing the activities of endogenous antibodies.
Molecular Cancer Therapeutics, 2011Abstract Many monoclonal antibodies (mAbs) exhibit activity through antibody dependent cellular cytotoxicity (ADCC), due to the binding interactions between the Fc portion of the mAb and Fc RIIIa on natural killer cells, macrophages and neutrophils.
Stephen Alley +6 more
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An improved synthesis of the C42–C52 segment of ciguatoxin 3C
Tetrahedron Letters, 2018Abstract In our previously reported method for the construction of the IJKLM-ring of ciguatoxin 3C (CTX3C), the lengthy synthetic process for the intermediate C42–C52 (L-ring) segment was problematic. Therefore, a new and improved procedure for the C42–C52 segment, having modified protecting groups, was developed.
Takafumi Saito +8 more
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The Journal of Chemical Physics, 2007
The 437 classical isomers of fullerene C52 have been studied by PM3, HCTH/3-21G, and B3LYP∕6-31G(d). C2:029 with the least number of adjacent pentagons is predicted to be the most stable isomer. The investigations show that both the number of adjacent pentagons and the degree of aromaticity play important roles in the relative stabilities of fullerene ...
De-Li, Chen +3 more
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The 437 classical isomers of fullerene C52 have been studied by PM3, HCTH/3-21G, and B3LYP∕6-31G(d). C2:029 with the least number of adjacent pentagons is predicted to be the most stable isomer. The investigations show that both the number of adjacent pentagons and the degree of aromaticity play important roles in the relative stabilities of fullerene ...
De-Li, Chen +3 more
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Stereoselective Synthesis of the C31−C40/C43−C52 Unit of Amphidinol 3
The Journal of Organic Chemistry, 2009A concise synthesis of a tetrahydropyran ring system corresponding to the C31-C40 and C43-C52 units of amphidinol 3 is described. Successive chemoselective reactions, i.e., cross-metathesis to differentiate the iodoolefin from the terminal olefin and Sharpless asymmetric dihydroxylation on the resulting E-olefin, resulted in expeditious synthesis of an
Mitsunori, Kanemoto +2 more
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The carbon pentamer dication C52+: Toward thermochemical stability
The Journal of Chemical Physics, 2003Various computational ab-initio methods are employed to study the doubly-charged carbon system C52+. For its electronic ground state, equilibrium geometries are identified, and their stability against dissociation investigated. Multireference configuration-interaction results indicate a weakly bound but thermochemically stable dication.
H. Hogreve, A. F. Jalbout
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Abstract C52: A novel combinatorial treatment for glioblastoma of temozolomide and JLK1486.
Molecular Cancer Therapeutics, 2013Abstract Background: Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly invasive and resistant to chemotherapeutic treatments. The current standard of care, comprised of surgical resection followed by radiation and chemotherapy, only provides GBM patients with a 12-
Jessica L. Weatherbee +3 more
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Abstract C52: Induction of homologous recombination by DNA nicks
Cancer Research, 2013Abstract Homologous recombination (HR) is a major mechanism of DNA repair, such that mutations in HR genes are associated with tumor susceptibility. We have used a recently adapted system for genome engineering to study HR mechanisms in mammalian cells.
Lianne E.M. Vriend +2 more
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C52-23 Pneumopericardium: An Elusive Diagnosis in the Polytrauma Patient
American Journal of Respiratory and Critical Care MedicineAbstract Pneumopericardium refers to the presence of air or gas within the pericardial sac. It most commonly results from a fistulous connection between the pericardium and air-containing structures like the thoracic cavity or GI tract, though congenital causes exist. Approximately 60% of cases are trauma-related, predominantly due to
L Mead, R Ringersen, S Gray, B Dieudonne
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