Results 1 to 10 of about 4,217 (211)

The distinct effects of orally administered Lactobacillus rhamnosus GG and Lactococcus lactis subsp. lactis C59 on gene expression in the murine small intestine [PDF]

PLoS ONE, 2017
The molecular mechanisms of strain-specific probiotic effects and the impact of the oral administration of probiotic strains on the host's gene expression are not yet well understood.
Chise Suzuki, Yoshiharu Takayama, Koko Mizumachi   +2 more
exaly   +3 more sources

Targeting Wnt/β-catenin activation in combination with temozolomide leads to glioblastoma inhibition and long-term survival in mice [PDF]

Genes and Diseases
Glioblastoma (GBM) is one of the most treatment-resistant brain malignancies. Dysregulation of Wnt/β-catenin signaling might be implicated in tumorigenesis of GBM.
Xiaowei Zhang, Zhongyong Wang, Taohui Ouyang, Brayden Wang, Richard I. Joh, Suyun Huang   +5 more
doaj   +3 more sources

Short-Term Oral Administration of the Porcupine Inhibitor, Wnt-c59, Improves the Structural and Functional Features of Experimental HFpEF. [PDF]

Pharmacol Res Perspect
ABSTRACTHeart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases globally, and this incidence is increasing due to extended lifespans and accumulating comorbidities. Emerging evidence suggests that Wnt signaling plays a role in cardiomyocyte hypertrophy and cardiac fibrosis, which are key features of ...
Paul MA, Wainwright CL, Hector EE, Ryberg E, Leslie SJ, Walsh SK.   +5 more
europepmc   +6 more sources

Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection [PDF]

Scientific Reports
High-yield influenza virus production is essential for efficient vaccine manufacturing to support global demands. Using Madin-Darby canine kidney (MDCK) cells to produce influenza viruses is an attractive alternative to the conventional method of ...
Jocelyn A. Menard, Tilia Zinnecker, Elena Godbout, Joshua A. Roberts, Rozanne Arulanandam, Andrew Chen, Anne Landry, Christopher N. Boddy, Udo Reichl, Jean-Simon Diallo, Yvonne Genzel, Jeffrey C. Smith   +11 more
doaj   +2 more sources

Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB

International Journal of Molecular Sciences, 2021
Sepsis is characterized by multiple-organ dysfunction caused by the dysregulated host response to infection. Until now, however, the role of the Wnt signaling has not been fully characterized in multiple organs during sepsis.
Jaewoong Jang, Young V Kwon, Yoosik Yoon   +2 more
exaly   +2 more sources

WNT-C59, a Small-Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells [PDF]

Stem Cells Translational Medicine, 2016
The recapitulation of human neural development in a controlled, defined manner from pluripotent stem cells (PSCs) has considerable potential for studies of human neural development, circuit formation and function, and the construction of in vitromodels ...
Takenori Ogura, Jun Takahashi, Takahashi Jun   +2 more
exaly   +2 more sources

Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue [PDF]

Molecular Metabolism
Objectives: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin.
Ayushi Mittal, Paul Buscaglia, Dhiraj Srivastava, Nikolai O. Artemyev, Julien A. Sebag   +4 more
doaj   +2 more sources

Inhibiting Wnt Signaling Reduces Cholestatic Injury by Disrupting the Inflammatory AxisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: β-Catenin, the effector molecule of the Wnt signaling pathway, has been shown to play a crucial role in bile acid homeostasis through direct inhibition of farnesoid X receptor (FXR), which has pleiotropic effects on bile acid ...
Mary Ayers, Karis Kosar, Yuhua Xue, Chhavi Goel, Matthew Carson, Elizabeth Lee, Silvia Liu, Eva Brooks, Pamela Cornuet, Michael Oertel, Bharat Bhushan, Kari Nejak-Bowen   +11 more
doaj   +2 more sources

Effect of Graphite Morphology on the Electrochemical and Mechanical Properties of SiO_x/Graphite Composite Anode

Batteries, 2023
Mixing SiOx materials with graphite materials has become a key technology to improve their performance, but it is still unclear what kind of graphite materials help to construct a stable electrode structure.
Chenyang Wang, Tianyi Ma, Xingge Liu, Zhi Liu, Zenghua Chang, Jing Pang   +5 more
doaj   +2 more sources

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway [PDF]

Medical Science Monitor, 2020
BACKGROUND Cardiac hypertrophy usually results in heart failure and is an important cause of mortality worldwide. Wnt/ß-catenin signaling pathway hyper-activation is involved in the pathogenesis and progression of cardiac hypertrophy. Wnt-C59 is a small molecular compound, which strongly and specifically targets at Porcupine to pharmacologically ...
Zhao, Zhengbo, Liu, Han, Li, Yu, Tian, Jingxiu, Deng, Songbai   +4 more
exaly   +3 more sources