The distinct effects of orally administered Lactobacillus rhamnosus GG and Lactococcus lactis subsp. lactis C59 on gene expression in the murine small intestine [PDF]
PLoS ONE, 2017 The molecular mechanisms of strain-specific probiotic effects and the impact of the oral administration of probiotic strains on the host's gene expression are not yet well understood.
Chise Suzuki, Keisuke Sasaki, Reiji Aoki
exaly +3 more sources
Targeting Wnt/β-catenin activation in combination with temozolomide leads to glioblastoma inhibition and long-term survival in mice [PDF]
Genes and DiseasesGlioblastoma (GBM) is one of the most treatment-resistant brain malignancies. Dysregulation of Wnt/β-catenin signaling might be implicated in tumorigenesis of GBM.
Xiaowei Zhang +5 more
doaj +3 more sources
Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection [PDF]
Scientific ReportsHigh-yield influenza virus production is essential for efficient vaccine manufacturing to support global demands. Using Madin-Darby canine kidney (MDCK) cells to produce influenza viruses is an attractive alternative to the conventional method of ...
Jocelyn A. Menard +11 more
doaj +2 more sources
Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue [PDF]
Molecular MetabolismObjectives: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin.
Ayushi Mittal +4 more
doaj +2 more sources
BDSet: A First-ever BDS Satellite-based PPP Augmentation Dataset Since 2023 [PDF]
Scientific DataThe BDS precise point positioning (PPP) service broadcasts state space representation (SSR) corrections via PPP-B2b augmentation signals. To maximize research potentials of the service, this study develops a first-ever BDS PPP-B2b augmentation dataset ...
Chenhao Ouyang +5 more
doaj +2 more sources
Structural basis for Porcupine inhibition [PDF]
Communications ChemistryWnt signalling is essential for embryonic development and tissue homeostasis, and its dysregulation is associated with multiple types of cancer. Porcupine (PORCN), an endoplasmic reticulum (ER)-resident membrane-bound O-acyltransferase, catalyses the ...
Katrina A. Black +8 more
doaj +2 more sources
Crystal structure of fucoxanthin: resolving a long-standing crystallographic challenge. [PDF]
Acta Crystallogr C Struct ChemThe first small‐molecule single‐crystal X‐ray structure of fucoxanthin is reported, resolving a long‐standing crystallographic problem in carotenoid structural chemistry.Fucoxanthin (C42H58O6) is a highly functionalized allenic epoxy xanthophyll containing hydroxy, acetoxy, ketone and conjugated polyene units.
Wakasa Y, Minoura M.
europepmc +2 more sources
Stability of C59 Knockout Fragments from Femtoseconds to Infinity
Astrophysical JournalWe have studied the stability of C _59 anions as a function of time, from their formation on femtosecond timescales to their stabilization on second timescales and beyond, using a combination of theory and experiments. The ${{\rm{C}}}_{59}^{-}$ fragments
Michael Gatchell +11 more
exaly +2 more sources
Inhibiting Wnt Signaling Reduces Cholestatic Injury by Disrupting the Inflammatory AxisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: β-Catenin, the effector molecule of the Wnt signaling pathway, has been shown to play a crucial role in bile acid homeostasis through direct inhibition of farnesoid X receptor (FXR), which has pleiotropic effects on bile acid ...
Mary Ayers +11 more
doaj +1 more source
Folia Oeconomica Stetinensia, 2023 By launching a war against Ukraine, Russia changed the entire world system and demonstrated the ineffectiveness of the global security system. Today it is necessary to look for effective solutions to support the adoption of security decisions and develop
Berezka Kateryna M., Kovalchuk Olha Ya.
doaj +1 more source