Results 21 to 30 of about 126,879 (240)

Global offshore wind energy resources using the new ERA-5 reanalysis

Environmental Research Letters, 2020
A global quantitative characterization of offshore wind power density is presented over the economic exclusive zones (EEZs), at annual and seasonal scales, based on the recently released ECMWF ERA-5 reanalysis.
Pedro M M Soares, Daniela C A Lima, Miguel Nogueira   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Life Situation of Polish Seniors – Their Subjective Assessment

Folia Oeconomica Stetinensia
Seniors wield influence across a spectrum of social spheres. Understanding their attitudes, needs, challenges, and expectations emerges as imperative for shaping effective social policies and social inclusion. Their significant heterogeneity necessitates
Przybysz Klaudia, Stanimir Agnieszka
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

REDESIGNING PRESERVICE MATHEMATICS TEACHER’S LESSON PLAN BY USING PRODUCTIVE PEDAGOGIES FRAMEWORK [PDF]

Journal of Engineering Science and Technology, 2018
This paper aims at describing an innovative course which encourages presevice teachers to reflect on their quality of instructional plan as well as its implementation within a field teaching experience and to redesign lesson plan based on the four ...
ABADI ABADI, ROOSELYNA EKAWATI
doaj  

Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation

Frontiers in Chemistry, 2020
Gp36 is the virus envelope glycoproteins catalyzing the fusion of the feline immunodeficiency virus with the host cells. The peptide C8 is a tryptophan-rich peptide corresponding to the fragment 770W-I777 of gp36 exerting antiviral activity by binding ...
Daniele Di Marino, Agostino Bruno, Manuela Grimaldi, Mario Scrima, Ilaria Stillitano, Giuseppina Amodio, Grazia Della Sala, Alice Romagnoli, Augusta De Santis, Ornella Moltedo, Paolo Remondelli, Giovanni Boccia, Gerardino D'Errico, Anna Maria D'Ursi, Vittorio Limongelli, Vittorio Limongelli   +15 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Gravitational baryogenesis beyond the spectator approximation

Physics Letters B
The standard gravitational-baryogenesis operator λ ∇μR Jμ, with λ≡ϵ/M*2, is usually treated as a spectator interaction that generates an effective chemical potential in a prescribed background.
David S. Pereira, Beatriz A. Fernandes, José Pedro Mimoso   +2 more
doaj   +1 more source

Use of Serotonergic Drugs in Canada for Gastrointestinal Motility Disorders: Results of a Retrospective Cohort Study

Scientifica, 2016
Background. Surgery for GI dysmotility is limited to those with severe refractory disease. Though effective, use of serotonergic promotility drugs has been restricted in Canada due to adverse events.
Biniam Kidane, Farouq Manji, Jennifer Lam, Brian M. Taylor   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source