Results 1 to 10 of about 12,468 (113)

Complement Components C1r and C8 Serve as Potential Inflammatory Biomarkers for Coronary Heart Disease Severity: The Mediating Role of C-Reactive Protein [PDF]

Journal of Inflammation Research
Xia Feng,1– 4,* Xiaoting Jiang,1– 4,* Shaolin Gong,1– 4,* Wen Liu,1– 4 Qiong Yan,1 Hongmei Qi,1 Ling Yu,1 Xiang Wang,1– 4 Xiaoping Peng1– 4 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College ...
Feng X, Jiang X, Gong S, Liu W, Yan Q, Qi H, Yu L, Wang X, Peng X   +8 more
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Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells [PDF]

Frontiers in Immunology
BackgroundLocal expression of complement components in the kidney has been reported sporadically in both diseased and normal kidneys. This study aimed to comprehensively characterize the expression of complement components in human glomerular mesangial ...
Yueming Gao, Qi Li, Yue Wang, Zhenling Deng   +3 more
doaj   +2 more sources

Sera from Phylogenetically Related Alligators, Crocodiles and Domestic Chickens Exhibit Comparable Anti-Cancer Activity [PDF]

Cells
Background: Crocodilians rarely develop cancer despite long lifespans and continuous exposure to environmental carcinogens, suggesting robust natural anti-tumor defense mechanisms.
Ofer Binah, Gil Shalev, Gila Maor, Irina Reiter, Inbal Ziv, Aaron Ciechanover   +5 more
doaj   +2 more sources

AlphaFold reveals how pathogenic Leptospira use cross-kingdom thiol-disulfide exchange to evade the complement membrane attack complex [PDF]

mBio
Leptospirosis is a globally significant severe infectious disease that affects a range of mammals. To understand its complex aetiopathogenesis, Leptospira spp.
Abbie Hinds, Emily Johnson, Gareth Staton, Ferdinand N. Njume, Hayley E. Crosby-Durrani, Jarlath E. Nally, Stuart Carter, Daniel J. Rigden, Nicholas J. Evans   +8 more
doaj   +2 more sources

Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]

EMBO Reports
Human immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek   +7 more
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Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of Klebsiella pneumoniae. [PDF]

PLoS Pathogens
Membrane Attack Complex (MAC) pores are important in the human innate immune response to directly kill pathogenic Gram-negative bacteria. MAC pores assemble when complement proteins in serum are activated on bacteria and convert complement protein C5 ...
Kulsum M Dawoodbhoy, Coco R Beudeker, Panagiotis Theofilidis, Frerich M Masson, Michiel van der Flier, Suzan H M Rooijakkers, Bart W Bardoel, Dennis J Doorduijn   +7 more
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Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun, Xi Zhao, Zixia Wang, Jing Yang, Limei Zhao, Bin Zhan, Xinping Zhu   +6 more
doaj   +1 more source

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis

Frontiers in Medicine, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the interstitium of the lung.
Liv I. B. Sikkeland, Liv I. B. Sikkeland, Thor Ueland, Thor Ueland, Thor Ueland, May B. Lund, May B. Lund, Michael Thomas Durheim, Michael Thomas Durheim, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes   +12 more
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Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]

PLoS ONE, 2012
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer   +11 more
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The oxygen carrier M101 alleviates complement activation, which may be beneficial for donor organ preservation

Frontiers in Immunology, 2022
During organ transplantation, ischemia/reperfusion injury and pre-formed anti-HLA antibodies are the main cause of delayed graft function and recovery through the activation of the complement system.
Bénédicte Puissant-Lubrano, Bénédicte Puissant-Lubrano, Charlène Bouthemy, Nicolas Congy-Jolivet, Nicolas Congy-Jolivet, Jean Milhes, Vincent Minville, Nassim Kamar, Nassim Kamar, Leïla Demini, Franck Zal, Yves Renaudineau, Yves Renaudineau   +12 more
doaj   +1 more source