Results 21 to 30 of about 419,621 (293)
PLoS Pathogens, 2021 Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers ...
Dennis J Doorduijn +7 more
doaj +2 more sources
The effect of colostrum period management on BW and immune system in lambs: from birth to weaning
Animal, 2015 The aim of this study was to investigate the BW and immune status of lambs reared under natural conditions or under artificial conditions fed two different colostrum amounts.
L.E. Hernández-Castellano +5 more
doaj +1 more source
Establishing a Case for Anti-complement Therapy in Membranous Nephropathy
Kidney International Reports, 2021 Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG.
Isabelle Ayoub +16 more
doaj +1 more source
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström +14 more
core +1 more source
Frontiers in Immunology, 2018 Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under ...
Mariana Gaya da Costa +15 more
doaj +1 more source
Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]
PLoS Neglected Tropical Diseases, 2011 BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang +8 more
doaj +1 more source
FEBS Letters, 1994 The β‐chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B (‘basic’) and C8B A (‘acidic’)). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA → GGA) and demonstrate that the resulting amino acid substitution (Arg →
Dewald, Georg +2 more
openaire +2 more sources
Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. [PDF]
, 2011 BACKGROUND\ud \ud Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Fried, Michal +7 more
core +1 more source
Soluble Membrane Attack Complex: Biochemistry and Immunobiology
Frontiers in Immunology, 2020 The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin.
Scott R. Barnum +2 more
doaj +1 more source
COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
, 1993 Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ +10 more
core +1 more source