Results 21 to 30 of about 47,794 (286)

Human complement component C8

FEBS Letters, 1994
The β‐chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B (‘basic’) and C8B A (‘acidic’)). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA → GGA) and demonstrate that the resulting amino acid substitution (Arg →
Dewald, Georg, Hemmer, Susanne, Nöthen, Markus M.   +2 more
openaire   +2 more sources

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Animal, 2015
The aim of this study was to investigate the BW and immune status of lambs reared under natural conditions or under artificial conditions fed two different colostrum amounts.
L.E. Hernández-Castellano, A. Suárez-Trujillo, D. Martell-Jaizme, G. Cugno, A. Argüello, N. Castro   +5 more
doaj   +1 more source

Deterministic Polynomial-Time Algorithms for Designing Short DNA Words [PDF]

, 2012
Designing short DNA words is a problem of constructing a set (i.e., code) of n DNA strings (i.e., words) with the minimum length such that the Hamming distance between each pair of words is at least k and the n words satisfy a set of additional ...
Kao, Ming-Yang, Leung, Henry C. M., Sun, He, Zhang, Yong   +3 more
core   +2 more sources

Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang, Jing Yang, Junfei Wei, Yaping Yang, Xiaoqin Chen, Xi Zhao, Yuan Gu, Shijuan Cui, Xinping Zhu   +8 more
doaj   +1 more source

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

Frontiers in Immunology, 2018
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under ...
Mariana Gaya da Costa, Felix Poppelaars, Felix Poppelaars, Cees van Kooten, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Francesco Tedesco, Reinhard Würzner, Leendert A. Trouw, Leendert A. Trouw, Lennart Truedsson, Mohamed R. Daha, Mohamed R. Daha, Anja Roos, Marc A. Seelen   +15 more
doaj   +1 more source

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Frontiers in Immunology, 2020
The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin.
Scott R. Barnum, Doryen Bubeck, Theresa N. Schein   +2 more
doaj   +1 more source

Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
The complement system is a part of the natural immune regulation mechanism against invading pathogens. Complement activation from three different pathways (classical, lectin, and alternative) leads to the formation of C5-convertase, an enzyme for ...
D. V. A. Khoa, K. Wimmers
doaj   +1 more source

Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man. Reconstitution of normal C8 from the mixture of two abnormal C8 molecules. [PDF]

Journal of Clinical Investigation, 1983
Restoration of hemolytic activity was examined in sera from seven unrelated eighth component of complement (C8)-deficient subjects. The sera fell into two groups, depending on whether hemolytic activity was restored by the addition of the beta-chain (group 1) or the alpha-gamma-subunit (group 2) purified from normal human C8.
F, Tedesco, P, Densen, M A, Villa, B H, Petersen, G, Sirchia   +4 more
openaire   +2 more sources

Deficiency of the Seventh Component of Complement in a Taiwanese Boy

Journal of the Formosan Medical Association, 2006
Inherited complement deficiencies are rare, particularly those associated with late components of the complement cascade. We report a 5-year-4-month-old Taiwanese boy with systemic meningococcal infection who had undetectable CH50 level of < 6 U/mL ...
Yi-Chi Chiang, Shyh-Dar Shyur, Li-Hsin Huang, Ta-Chzng Wen, Mao-Tsair Lin, Hwai-Chih Yang, Pei-Hsuan Liang   +6 more
doaj   +1 more source

Proteomic Analysis of Complement Proteins in Membranous Nephropathy

Kidney International Reports, 2020
Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in Caucasian adults. Phospholipase A2 receptor (PLA2R)– and exostosin 1 (EXT1)/exostosin 2 (EXT2)–associated MN represent the most common primary and secondary forms
Aishwarya Ravindran, Benjamin Madden, M. Cristine Charlesworth, Rishi Sharma, Amit Sethi, Hanna Debiec, Daniel Cattran, Fernando C. Fervenza, Richard J. Smith, Pierre Ronco, Sanjeev Sethi   +10 more
doaj   +1 more source