Results 21 to 30 of about 11,877 (255)
Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]
PLoS ONE, 2012 Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika +11 more
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Frontiers in Immunology, 2022 During organ transplantation, ischemia/reperfusion injury and pre-formed anti-HLA antibodies are the main cause of delayed graft function and recovery through the activation of the complement system.
Bénédicte Puissant-Lubrano +12 more
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Journal of Innate Immunity, 2023 The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C ...
Marco Mannes +16 more
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Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis [PDF]
PeerJ, 2023 Aim IgA nephropathy (IgAN) is one of the leading causes of end-stage renal disease (ESRD). Urine testing is a non-invasive way to track the biomarkers used for measuring renal injury.
Xia Niu +10 more
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Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System
Frontiers in Immunology, 2020 The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi +5 more
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Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement
Frontiers in Immunology, 2023 Antibodies to red blood cells (RBCs) may hemolyze erythrocytes via Fc-mediated phagocytosis or complement-dependent. Complement activation on RBCs can be detected by C3d-direct antiglobulin test (DAT), which is the only test in immune hematology that ...
Thilo Bartolmäs +2 more
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Identity of the Segment of Human Complement C8 Recognized by Complement Regulatory Protein CD59 [PDF]
Journal of Biological Chemistry, 1995 CD59 antigen is a membrane glycoprotein that inhibits the activity of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The inhibitory function of CD59 derives from its capacity to interact with both the C8 and C9 components of MAC, preventing assembly of membrane-inserted C9 polymer. MAC-inhibitory
D H, Lockert +5 more
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PLoS Pathogens, 2021 Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers ...
Dennis J Doorduijn +7 more
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Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies
Frontiers in Immunology, 2019 The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial ...
Carine El Sissy +13 more
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Establishing a Case for Anti-complement Therapy in Membranous Nephropathy
Kidney International Reports, 2021 Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG.
Isabelle Ayoub +16 more
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