Results 11 to 20 of about 419,621 (293)

Structure of human complement C8, a precursor to membrane attack. [PDF]

J Mol Biol, 2011
Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no ...
Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM.   +5 more
europepmc   +8 more sources

The Role of Complement in Cancer Immunotherapy [PDF]

, 2022
The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...

core   +1 more source

The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits [PDF]

Biochemical Journal, 1988
1. Ten mouse monoclonal antibodies to human complement component C8 were prepared. It was found that six of these antibodies reacted with the alpha-subunit, two with the beta-subunit and two with the gamma-subunit, when assessed by immunoblotting after separation of C8 subunits by SDS/polyacrylamide-gel electrophoresis. 2.
A, Abraha, B P, Morgan, J P, Luzio
openaire   +2 more sources

Identity of the Segment of Human Complement C8 Recognized by Complement Regulatory Protein CD59 [PDF]

Journal of Biological Chemistry, 1995
CD59 antigen is a membrane glycoprotein that inhibits the activity of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The inhibitory function of CD59 derives from its capacity to interact with both the C8 and C9 components of MAC, preventing assembly of membrane-inserted C9 polymer. MAC-inhibitory
D H, Lockert, K M, Kaufman, C P, Chang, T, Hüsler, J M, Sodetz, P J, Sims   +5 more
openaire   +2 more sources

Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System

Frontiers in Immunology, 2020
The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi, Britta Schiela, Sarah Bernklau, Zoltan Banki, Reinhard Würzner, Heribert Stoiber   +5 more
doaj   +1 more source

Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

Journal of Innate Immunity, 2023
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C ...
Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang   +16 more
doaj   +1 more source

Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis [PDF]

PeerJ, 2023
Aim IgA nephropathy (IgAN) is one of the leading causes of end-stage renal disease (ESRD). Urine testing is a non-invasive way to track the biomarkers used for measuring renal injury.
Xia Niu, Shuyu Zhang, Chen Shao, Zhengguang Guo, Jianqiang Wu, Jianling Tao, Ke Zheng, Wenling Ye, Guangyan Cai, Wei Sun, Mingxi Li   +10 more
doaj   +2 more sources

Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement

Frontiers in Immunology, 2023
Antibodies to red blood cells (RBCs) may hemolyze erythrocytes via Fc-mediated phagocytosis or complement-dependent. Complement activation on RBCs can be detected by C3d-direct antiglobulin test (DAT), which is the only test in immune hematology that ...
Thilo Bartolmäs, Axel Pruß, Beate Mayer   +2 more
doaj   +1 more source

Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

Frontiers in Immunology, 2019
The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial ...
Carine El Sissy, Jérémie Rosain, Paula Vieira-Martins, Pauline Bordereau, Aurélia Gruber, Magali Devriese, Loïc de Pontual, Muhamed-Kheir Taha, Claire Fieschi, Claire Fieschi, Capucine Picard, Capucine Picard, Véronique Frémeaux-Bacchi, Véronique Frémeaux-Bacchi   +13 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source