Results 11 to 20 of about 11,877 (255)

Complement Components C1r and C8 Serve as Potential Inflammatory Biomarkers for Coronary Heart Disease Severity: The Mediating Role of C-Reactive Protein [PDF]

Journal of Inflammation Research
Xia Feng,1– 4,* Xiaoting Jiang,1– 4,* Shaolin Gong,1– 4,* Wen Liu,1– 4 Qiong Yan,1 Hongmei Qi,1 Ling Yu,1 Xiang Wang,1– 4 Xiaoping Peng1– 4 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College ...
Feng X, Jiang X, Gong S, Liu W, Yan Q, Qi H, Yu L, Wang X, Peng X   +8 more
doaj   +2 more sources

Structure of human complement C8, a precursor to membrane attack.

J Mol Biol, 2011
Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no ...
Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM.   +5 more
europepmc   +7 more sources

Sera from Phylogenetically Related Alligators, Crocodiles and Domestic Chickens Exhibit Comparable Anti-Cancer Activity [PDF]

Cells
Background: Crocodilians rarely develop cancer despite long lifespans and continuous exposure to environmental carcinogens, suggesting robust natural anti-tumor defense mechanisms.
Ofer Binah, Gil Shalev, Gila Maor, Irina Reiter, Inbal Ziv, Aaron Ciechanover   +5 more
doaj   +2 more sources

Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]

EMBO Reports
Human immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek   +7 more
doaj   +2 more sources

Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae [PDF]

mBio
The complement cascade is a front-line defense against pathogens. Complement activation generates the membrane attack complex (MAC), a 10–11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. The MAC embeds within the outer
Evan R. Lamb, Alison K. Criss
doaj   +2 more sources

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of Klebsiella pneumoniae. [PDF]

PLoS Pathogens
Membrane Attack Complex (MAC) pores are important in the human innate immune response to directly kill pathogenic Gram-negative bacteria. MAC pores assemble when complement proteins in serum are activated on bacteria and convert complement protein C5 ...
Kulsum M Dawoodbhoy, Coco R Beudeker, Panagiotis Theofilidis, Frerich M Masson, Michiel van der Flier, Suzan H M Rooijakkers, Bart W Bardoel, Dennis J Doorduijn   +7 more
doaj   +2 more sources

Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes [PDF]

Acta Neuropathologica Communications
Background Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying ...
André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder I. Nakaya, Andréa Laurato Sertié, Bruna Lancia Zampieri   +7 more
doaj   +2 more sources

Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun, Xi Zhao, Zixia Wang, Jing Yang, Limei Zhao, Bin Zhan, Xinping Zhu   +6 more
doaj   +1 more source

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis

Frontiers in Medicine, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the interstitium of the lung.
Liv I. B. Sikkeland, Liv I. B. Sikkeland, Thor Ueland, Thor Ueland, Thor Ueland, May B. Lund, May B. Lund, Michael Thomas Durheim, Michael Thomas Durheim, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes   +12 more
doaj   +1 more source

The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits [PDF]

Biochemical Journal, 1988
1. Ten mouse monoclonal antibodies to human complement component C8 were prepared. It was found that six of these antibodies reacted with the alpha-subunit, two with the beta-subunit and two with the gamma-subunit, when assessed by immunoblotting after separation of C8 subunits by SDS/polyacrylamide-gel electrophoresis. 2.
A, Abraha, B P, Morgan, J P, Luzio
openaire   +2 more sources