Results 11 to 20 of about 47,794 (286)

Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System

Frontiers in Immunology, 2020
The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi, Britta Schiela, Sarah Bernklau, Zoltan Banki, Reinhard Würzner, Heribert Stoiber   +5 more
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Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement

Frontiers in Immunology, 2023
Antibodies to red blood cells (RBCs) may hemolyze erythrocytes via Fc-mediated phagocytosis or complement-dependent. Complement activation on RBCs can be detected by C3d-direct antiglobulin test (DAT), which is the only test in immune hematology that ...
Thilo Bartolmäs, Axel Pruß, Beate Mayer   +2 more
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Identity of the Segment of Human Complement C8 Recognized by Complement Regulatory Protein CD59 [PDF]

Journal of Biological Chemistry, 1995
CD59 antigen is a membrane glycoprotein that inhibits the activity of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The inhibitory function of CD59 derives from its capacity to interact with both the C8 and C9 components of MAC, preventing assembly of membrane-inserted C9 polymer. MAC-inhibitory
D H, Lockert, K M, Kaufman, C P, Chang, T, Hüsler, J M, Sodetz, P J, Sims   +5 more
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Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.

PLoS Pathogens, 2021
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers ...
Dennis J Doorduijn, Dani A C Heesterbeek, Maartje Ruyken, Carla J C de Haas, Daphne A C Stapels, Piet C Aerts, Suzan H M Rooijakkers, Bart W Bardoel   +7 more
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Invasive meningococcal disease in three siblings with hereditary deficiency of the 8th component of complement: Evidence for the importance of an early diagnosis [PDF]

, 2016
Deficiency of the eighth component of complement (C8) is a very rare primary immunodeficiency, associated with invasive, recurrent infections mainly caused by Neisseria species.
A Orren, AE Platonov, AE Platonov, AJ Turley, AS Grumach, CA Fijen, DF Arnold, EG Jorge de, F Bossi, J Andreoni, JE Figueroa, Laura Dell’Era, Luca De Maso, M Cugno, M Dahl, M Kuruvilla, MA Hadders, Mara Giordano, Maria Cristina Pietrogrande, Massimo Cugno, P Macor, Paola Pavesi, Paolo Macor, R Naidoor, Rosa Maria Dellepiane, S Hoare, SC Ross, T Kaufmann   +27 more
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Structural basis of complement membrane attack complex formation [PDF]

, 2015
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit’ mechanism; however, sublytic MAC pores on host cells activate ...
Bubeck, D, Giles, JL, Morgan, BP, Serna Gil, M   +3 more
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The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits [PDF]

Biochemical Journal, 1988
1. Ten mouse monoclonal antibodies to human complement component C8 were prepared. It was found that six of these antibodies reacted with the alpha-subunit, two with the beta-subunit and two with the gamma-subunit, when assessed by immunoblotting after separation of C8 subunits by SDS/polyacrylamide-gel electrophoresis. 2.
A, Abraha, B P, Morgan, J P, Luzio
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Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B [PDF]

, 1980
Serum protein types were determined in eight recipients and donors in cases of hepatic homotransplantation. A change from recipient type to donor type was observed for factor B, C8, orosomucoid, haptoglobin, transferrin, α1-antitrypsin, C3 and C6, but ...
Alper, Alper, Alper, Alper, Borel, Brade, Bruce H. Petersen, Chester A. Alper, Donald Raum, Einstein, Frants, Hirschfeld, Hobart, Hobart, Johnson, Kashiwagi, Kashiwagi, Kühnl, Merrill, Miller, Miller, Paul D. Taylor, Petersen, Raum, Rother, Smithies, Starzl, Thomas E. Starzl, Witherspoon, Zuheir L. Awdeh   +29 more
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Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

Frontiers in Immunology, 2019
The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial ...
Carine El Sissy, Jérémie Rosain, Paula Vieira-Martins, Pauline Bordereau, Aurélia Gruber, Magali Devriese, Loïc de Pontual, Muhamed-Kheir Taha, Claire Fieschi, Claire Fieschi, Capucine Picard, Capucine Picard, Véronique Frémeaux-Bacchi, Véronique Frémeaux-Bacchi   +13 more
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Establishing a Case for Anti-complement Therapy in Membranous Nephropathy

Kidney International Reports, 2021
Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG.
Isabelle Ayoub, John P. Shapiro, Huijuan Song, Xiaolan Lily Zhang, Samir Parikh, Salem Almaani, Sethu Madhavan, Sergey V. Brodsky, Anjali Satoskar, Cherri Bott, Lianbo Yu, Michael Merchant, John Klein, Juan M. Mejia-Vilet, Tibor Nadasdy, Dan Birmingham, Brad H. Rovin   +16 more
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