Results 41 to 50 of about 2,418,826 (273)

Be Wary Of CA 125 Levels [PDF]

open access: yes
Ca 125 a tumour marker for ovarian neoplasms. We did a retrospective study to assess the levels of CA 125 in patients with ovarian masses. It was surprising to find CA 125 levels being elevated in both malignant and benign ovarian masses.
Sunderraman, Dr. Shruthi   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Anticorps monovalents modifiés anti-CA 125 nouveaux inhibiteurs de l'antigène tumoral CA 125 [PDF]

open access: yes, 2003
CA 125 est un déterminant antigénique reconnu par l'anticorps monoclonal OC125. Une surexpression de la glycoprotéine CA 125 au niveau de la surface des ovaires est observée dans plus de 90% des cancers ovariens séreux, mais n'est pas ...
Beaudin, Julie
core   +1 more source

Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report

open access: yesGynecologic Oncology Reports, 2017
We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus.
Sarah V. Strickland   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Serun CA 19-9 and CA 125 in Pancreatic Cancer [PDF]

open access: yes, 1996
Background/Aims: Trial to diagnose pancreatic cancer with CA 19-9 and CA125 has been continued, but study is rare to predict extensiveness of pancreatic cancer with CA 19-9 and CA 125.
정재복
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Akut apandisitte Ca125, CA19.9 ve karsinoembriyonik antijen gibi tümör belirteçlerinin rolü

open access: yesGenel Tıp Dergisi, 2015
Amaç: Bu çalışmada, CA125, CA19.9 ve karsinoembriyonik antijen CEA gibi tümor belirteçlerinin serum değerlerinin akut apandisit AA tanısında herhangi bir değerinin olup olmadığı araştırıldı. Gereç ve yöntem: Akut apandisit tanısı ile ameliyat edilmiş
Sevil Kurban, Hande Köksal
doaj  

CA‐125 variation in acute heart failure: a single‐centre analysis

open access: yesESC Heart Failure, 2022
Aims A decrease in carbohydrate antigen 125 (CA‐125) predicts survival advantage in chronic heart failure (HF); the impact of its variation in acute HF is unknown. We studied the association of CA‐125 decrease with prognosis in acute HF.
Patrícia Lourenço   +6 more
doaj   +1 more source

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