Results 51 to 60 of about 34,079 (221)

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial. [PDF]

, 2017
Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer ...
Al-Hazzouri, Ahmed, Bendell, Johanna C, DeBusk, Laura M, Earwood, Chris, Guo, Shuangli, Ko, Andrew H, Lane, Cassie M, Murphy, Patrick B, Peyton, James D, Rodriguez, Francisco A, Shipley, Dianna L, Tempero, Margaret A, Waterhouse, David M, Womack, Mark S, Xiong, Henry Q   +14 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

CA19-9 as a therapeutic target in pancreatitis [PDF]

Annals of Translational Medicine, 2019
The glycan carbohydrate antigen 19-9 (CA19-9) is one of the most important and widely used biomarkers for pancreatic cancer. In 1979, Koprowski et al. first described CA 19-9 as a tumor antigen recognized by the monoclonal antibody NS19-9 (1).
Shingo, Kato, Kazufumi, Honda
openaire   +2 more sources

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Combining CRP and CA19-9 in a novel prognostic score in pancreatic ductal adenocarcinoma

Scientific Reports, 2021
Inflammation promotes tumor progression, induces invasion and metastatic spread. This retrospective study explored CRP, CA19-9, and routine laboratory values as preoperative prognostic factors in pancreatic cancer patients.
Anna M. Nurmi, Harri K. Mustonen, Ulf-Håkan Stenman, Hanna E. Seppänen, Caj H. Haglund   +4 more
doaj   +1 more source

Liver: Intrahepatic cholangiocarcinoma [PDF]

, 2009
Review on Liver: Intrahepatic cholangiocarcinoma, with data on clinics, and the genes ...
Aishima, S, Enjoji, M
core   +1 more source

To Evaluate Whether Pretreatment CA19‐9 and DUPAN‐2 Levels Can Serve as Predictive Markers to Guide the Choice Between NAT and Upfront Surgery in Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
NAT‐GS was significantly more effective only in patients with one tumor marker above the reference range, comparing those who achieved 12‐month MRFS with those who did not. ABSTRACT Aim Pancreatic cancer (PC) remains one of the most lethal malignancies, with early recurrence severely affecting prognosis even after curative resection.
Hiromichi Kawaida, Wataru Izumo, Ryo Saito, Hidetake Amemiya, Suguru Maruyama, Katsutoshi Shoda, Kensuke Shiraishi, Shinji Furuya, Yoshihiko Kawaguchi, Daisuke Ichikawa   +9 more
wiley   +1 more source

High carbohydrate antigen 19–9 levels indicate poor prognosis in patients with bladder cancer following radical cystectomy

Frontiers in Oncology
IntroductionOur team previously reported that elevated carbohydrate antigen (CA) 19–9 levels are associated with a worse prognosis in upper tract urothelial carcinoma (UTUC).
Sang Won So, Sang Won So, Jang Hee Han, Jang Hee Han, Hyeong Dong Yuk, Hyeong Dong Yuk, Chang Wook Jeong, Chang Wook Jeong, Cheol Kwak, Cheol Kwak, Ja Hyeon Ku, Ja Hyeon Ku, Seung-hwan Jeong, Seung-hwan Jeong   +13 more
doaj   +1 more source

Comparison of CEA and CA19-9 as a predictive factor for recurrence after curative gastrectomy in gastric cancer

BMC Surgery, 2022
Background Our aim of was to compare importance of the tumor markers (TMs) serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in prediction of recurrence after curative gastrectomy for gastric cancer.
Chikashi Shibata, Toru Nakano, Akihiro Yasumoto, Atsushi Mitamura, Kentaro Sawada, Hitoshi Ogawa, Tomoya Miura, Ichiro Ise, Kazuhiro Takami, Kuniharu Yamamoto, Yu Katayose   +10 more
doaj   +1 more source