Results 81 to 90 of about 667,052 (292)

Control of Ca2+ influx by manipulation of Ca2+ and/or Ca2+ antagonist in cardioplegic arrest.

Japanese Circulation Journal, 1993
Maximum deactivation of the contractile elements using Ca2+ minimizes oxygen requirements during global ischemia, Ca2+ antagonists and Ca(2+)-free cardioplegia solutions are methods by which the Ca2+ flux can be manipulated. This study was performed with 5 experimental groups: 1) Standard cardioplegia (with Ca2+), 2) Ca(2+)-free cardioplegia, 3) Ca(2+)-
K, Hashimoto, K ], Hahimoto K [corrected to Hashimoto, J P, Mashburn, R, Cartier, H V, Schaff   +4 more
openaire   +3 more sources

Poly(ADP-ribose) polymerase regulates transient receptor potential channel M2-dependent calpain activation in rd1 mouse retinal degeneration

Neural Regeneration Research
Inherited retinal degeneration refers to untreatable blinding diseases characterized by progressive photoreceptor loss. Photoreceptor degeneration is often associated with an excessive activation of poly(ADP-ribose) polymerase and Ca2+-dependent calpain ...
Jie Yan, Lei Kong, Zhijian Zhao, Qianlu Yang, Lan Wang, Qianxi Yang, Christian Harteneck, Kangwei Jiao, Zhulin Hu, François Paquet-Durand   +9 more
doaj   +1 more source

Highly Efficient Visible Light-Induced Ca2+ Chelation [PDF]

Calcium ion (Ca2+) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visi-ble light-activated Ca2+ chelators with high quantum yields of 0.39, 0.52, and 0.83.
Charitha, Guruge, Roberto, Peverati, Nishal M., Egodawaththa, Olivia, Rajhel, Jingxuan, Ma, Nasri, Nesnas, Alec B., Pabarue, Emily, Harris   +7 more
core   +2 more sources

Calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires ARALAR/AGC1-malate aspartate shuttle in intact cortical neurons [PDF]

, 2013
Neuronal respiration is controlled by ATP demand and Ca2++ but the roles played by each are unknown, as any Ca2++ signal also impacts on ATP demand. Ca2+can control mitochondrial function through Ca2++-regulated mitochondrial carriers, the aspartate ...
Rueda, Carlos, Saheki, Takeyori, Pardo, Beatriz, Satrustegui Gil Delgado, Jorgina, Rueda, Carlos B., Saheki, T., Llorente-Folch, Irene, Satrústegui, Jorgina, Arco, Araceli del, Amigo, Ignacio, Pardo Merino, Beatriz   +10 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

TMCO1 Is An ER Ca2+ Load-Activated Ca2+ Channel [PDF]

, 2016
Maintaining homeostasis of Ca2+stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+signaling and key cellular functions. The Ca2+-release-activated Ca2+(CRAC) channel is responsible for Ca2+influx and refilling after store depletion, but ...
Zheng, Qingyin, Wang, Qiao Chu, Tang, Tie Shan, Tan, Haiyan, Sun, Zhongshuai, Yang, Maojun, Yang, Yuxiu, Guo, Caixia, Yu, Jie, Chen, Quan, Wang, Xi, Wang, Fengli, Li, Xiaoling, Tang, Tie-Shan, Zhang, Bing, Zhou, Aimin, Liu, Yang, Wang, Heng, Wang, Qiao-Chu, Zhu, Shu, Zheng, Qiaoxia, Wang, Jiu Qiang, Li, Yang, Chai, Hao, Wang, Jiu-Qiang   +24 more
core   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Na+-Ca2+ exchanger modulates Ca2+ content in intracellular Ca2+ stores in rat osteoblasts [PDF]

Experimental & Molecular Medicine, 2007
Na+-Ca2+ exchanger (NCX) transports Ca2+ coupled with Na+ across the plasma membrane in a bi-directional mode. Ca2+ flux via NCX mediates osteogenic processes, such as formation of extracellular matrix proteins and bone nodules. However, it is not clearly understood how the NCX regulates cellular Ca2+ movements in osteogenic processes.
Sang Yong, Jung, Yong Joo, Park, Young Jun, Park, Seok Ho, Cha, Myung Za, Lee, Chang Kook, Suh   +5 more
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source