Results 71 to 80 of about 567,581 (297)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Effects of Ca2+ on the Cross-linking of Sea Cucumber Collagen Fibers during Thermal Processing
Shipin gongye ke-jiDuring the thermal processing of sea cucumbers, changes in the CFs structure affect their textural characteristics and can lead to certain nutritional losses.
Chen ZHANG +7 more
doaj +1 more source
Frontiers in Physiology, 2023 Thapsigargin (TG) inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump and, when applied acutely, it initiates a Ca2+ mobilisation that begins with the loss of Ca2+ from the endoplasmic reticulum (ER) and culminates with store-operated Ca2 ...
Tillman Pick +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Medicine Science, 2016 Since worldwide alcohol consumption, the understanding the mechanism of action of ethanol is important in the gastrointestinal tract. In this study we aimed to clarify the role of extracellular and intracellular calcium (Ca2+) on relaxations induced by ...
Derya Kaya, Naciye Yaktubay Dondas
doaj +1 more source
Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E. +2 more
core +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Signalling molecule “calcium” improves germination and growth of Sorghum bicolor seedlings under salt stress [PDF]
, 2021 >Magister Scientiae - MScAbiotic stress, mainly in the form of extreme temperatures, drought and salinity has caused major crop losses worldwide, putting a severe strain on agriculture.
Hendricks, Kaylin
core +1 more source
Control of Ca2+ influx by manipulation of Ca2+ and/or Ca2+ antagonist in cardioplegic arrest.
Japanese Circulation Journal, 1993 Maximum deactivation of the contractile elements using Ca2+ minimizes oxygen requirements during global ischemia, Ca2+ antagonists and Ca(2+)-free cardioplegia solutions are methods by which the Ca2+ flux can be manipulated. This study was performed with 5 experimental groups: 1) Standard cardioplegia (with Ca2+), 2) Ca(2+)-free cardioplegia, 3) Ca(2+)-
K, Hashimoto +4 more
openaire +3 more sources