Results 71 to 80 of about 618,626 (288)

Calcium homeostasis and role of ryanodine receptor type 1 (RyR1) in immune cells [PDF]

, 2010
Ryanodine receptors are intracellular Ca2+ release channels located in the membrane of the Endoplasmatic/Sarcoplasmatic Reticulum. Ryanodine receptor 1 isoform is preferentially expressed in skeletal muscle where it is responsible for release of Ca2 ...
Vukcevic, Mirko
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The role of ryanodine receptors in development [PDF]

, 2011
PhDCalcium ions (Ca2+) are fundamental to the regulation of many cellular processes; however, the coordination of these signals during embryogenesis is not well understood.
Wu, Houdini Ho-Tin
core   +4 more sources

Effects of Ca2+ on the Cross-linking of Sea Cucumber Collagen Fibers during Thermal Processing

Shipin gongye ke-ji
During the thermal processing of sea cucumbers, changes in the CFs structure affect their textural characteristics and can lead to certain nutritional losses.
Chen ZHANG, Hongyan LI, Hongxia CHE, Wancui XIE, Hang QI, Yongjun SUN, Wenming JU, Xiufang DONG   +7 more
doaj   +1 more source

Characteristics of Ca2+, Mg2+-dependent ATP hydrolysis in sperm cells of infertile men

Біологічні студії, 2020
Disturbances of fertilizing potential of spermatozoa are closely associated with dysfunction of ion-transporting ATPases, in particular Ca2+, Mg2+-АТРase.
O. I. Meskalo, R. V. Fafula, Z. D. Vorobets   +2 more
doaj   +1 more source

Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion [PDF]

, 1993
We examined the relationship between transsarcolemmal cation gradients and hypercontracture of cardiac myocytes in ischemia and reperfusion using adult rat ventricular myocytes superfused with buffer mimicking normal or ischemic extracellular fluid ...
J. P. Navas, Marsh, J. D., R. A. Kelly, J. D. Marsh, Krämer, Bernhard K., Kelly, R. A., Nishida, M., T. W. Smith, Smith, T. W., M. Nishida, B. Kraemer, Borzak, S., S. Borzak, Navas, J. P.   +13 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification [PDF]

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effects of 17β-oestradiol on rat detrusor smooth muscle contractility [PDF]

, 2009
The aim of this study was to investigate the effect of 17β-oestradiol (E2) on detrusor smooth muscle contractility and its possible neuroprotective role against ischaemic-like condition, which could arise during overactive bladder disease.
Keith L. Brain, Sgaragli, G, Giampietro Sgaragli, Pessina, F, Sgaragli, G., Pessina, F., Young, John, John S. Young, Valeri, A., Young, JS, Sgaragli, GIAN PIETRO, Valeri, A, Young, J. S., Aurora Valeri, Brain, K., Brain, K. L., Pessina, Federica, Federica Pessina, Brain, Keith; id_orcid, Brain, KL   +19 more
core   +1 more source