Results 61 to 70 of about 618,626 (288)

Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

Cell Reports, 2023
Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments.
Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’Du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran Van Nhieu   +17 more
doaj   +1 more source

On adaptor proteins shaping Ca2+ signals in activated B lymphocytes [PDF]

, 2008
Neumann K. On adaptor proteins shaping Ca2+ signals in activated B lymphocytes. Bielefeld (Germany): Bielefeld University; 2008.Signale des B-Zell-Antigenrezeptors (BZR) regeln sowohl die Aktivierung pathogenspezifischer B-Lymphozyten als auch die ...
Neumann, Konstantin
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review

Clocks & Sleep, 2023
Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing is an emerging field of research that investigates the influence of eating patterns on our circadian rhythm ...
Ahmed S. BaHammam, Abdulrouf Pirzada
doaj   +1 more source

Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations

Biophysical Journal, 1996
A simplified mechanism that mimics "adaptation" of the ryanodine receptor (RyR) has been developed and its significance for Ca2+(-)induced Ca2+ release and Ca2+ oscillations investigated. For parameters that reproduce experimental data for the RyR from cardiac cells, adaptation of the RyR in combination with sarco/endoplasmic reticulum Ca2+ ATPase Ca2+
Keizer, J., Levine, L.
openaire   +2 more sources

Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release [PDF]

, 2015
This work was supported by University of St. Andrews, Tenovus Scotland Grant T14/35 (to S. J. P.), British Heart Foundation Grant FS/14/69/31001 (to S. J.
Woodier, Jason, J. Woodier (7634894), S. J. Pitt (7634900), A. J. Stewart (7634897), Pitt, Samantha Jane, Stewart, Alan J., Rainbow, Richard D., Richard D. Rainbow (7619696)   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
Heinemann, Akos, Zoltán Bálint, Akos Heinemann, György Váró (417636), Végh Attila G., Fazakas Csilla, Olschewski Horst, Csilla Fazakas, Krizbai István A., Horst Olschewski, Heinemann Akos, Konya, Viktoria, Diana Zabini, Chandran Nagaraj, Nagaraj Chandran, Váró, György, Bálint Zoltán, Zoltán Bálint (142590), Zabini, Diana, György Váró, Andrea Olschewski, Csilla Fazakas (218764), Akos Heinemann (142582), Olschewski Andrea, Attila G Végh, Olschewski, Horst, Chandran Nagaraj (142558), Bálint, Zoltán, István A Krizbai, István A. Krizbai (218814), Imola Wilhelm (218768), Andrea Olschewski (142595), Fazakas, Csilla, Viktoria Konya, Diana Zabini (142555), Attila G. Végh (417635), Viktoria Konya (176778), Váró György, Krizbai, István Adorján, Wilhelm Imola, Horst Olschewski (142585), Zabini Diana, Konya Viktoria, Olschewski, Andrea, Végh, Attila Gergely, Imola Wilhelm, Wilhelm, Imola   +46 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Zádor, Ernő, Vér, Ágota, Szabó, András   +3 more
core   +2 more sources