Results 51 to 60 of about 2,956,613 (308)

Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

Frontiers in Cardiovascular Medicine, 2021
Background: Emerging evidence has showed that serum carbohydrate antigen 125 (CA 125) levels are associated with the severity and prognosis of heart failure. However, its role in pulmonary hypertension remains unclear. This study aimed to investigate the
Yi Zhang, Qi Jin, Qi Jin, Zhihui Zhao, Qing Zhao, Xue Yu, Xue Yu, Lu Yan, Xin Li, Anqi Duan, Chenhong An, Xiuping Ma, Changming Xiong, Qin Luo, Zhihong Liu   +14 more
doaj   +1 more source

L‘utilité du test CA 125

Forum Médical Suisse ‒ Swiss Medical Forum, 2019
Actuellement, le depistage par CA 125 et ultrason endovaginal n’est pas recommande pour la population generale. Il y a cependant des patientes qui peuvent beneficier d’un programme de depistage.
Gros, Louis, Boulat, Olivier, Sarivalasis, Apostolos   +2 more
openaire   +2 more sources

Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib. [PDF]

, 2020
BackgroundTransforming growth factor beta (TGF-β) signalling is involved in the development of hepatocellular carcinoma (HCC). We followed changes in biomarkers during treatment of patients with HCC with the TGF-βRI/ALK5 inhibitor galunisertib ...
Benhadji, Karim A, Cleverly, Ann, Estrem, Shawn T, Faivre, Sandrine, Gane, Ed, Giannelli, Gianluigi, Kelley, Robin K, Lahn, Michael M, Man, Michael, Paradis, Valerie, Raymond, Eric, Santoro, Armando, Smith, Claire, Wang, Shuaicheng   +13 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sr/Ca ratios and oxygen isotopes from sclerosponges: Temperature history of the Carribean mixed layer and thermocline during the Little Ice Age [PDF]

, 2003
We investigate aragonitic skeletons of the Caribbean sclerosponge Ceratoporella nicholsoni from Jamaica, 20 m below sea level (mbsl), and Pedro Bank, 125 mbsl. We use d18O and Sr/Ca ratios as temperature proxies to reconstruct the Caribbean mixed layer
Aharon, Alexandra Haase-Schramm, Anton Eisenhauer, Benavides, Bent Hansen, Black, Böhm, Böhm, Böhm, Böhm, Chen, Corrège, Crowley, Crowley, Curtis, De Villiers, De Villiers, Delworth, DeMenocal, Druffel, Druffel, Dunbar, Edwards, Edwards, Eisenhauer, Enfield, Enmar, Evans, Fairbanks, Florian Böhm, Fratantoni, Ghil, Gordon, Haug, Hemming, Hernández-Guerra, Joachim Reitner, Joachimski, Jones, Kaplan, Keigwin, Kinsman, Lazareth, Levitus, Lough, Mann, Mann, McConnaughey, Michael M. Joachimski, Molinari, Moore, Morrison, Müller, Müller, Nadeau, Reitner, Reitner, Roberts, Rosenheim, Rühlemann, Schmitz, Schmitz, Shen, Shindell, Sprintall, Stott, Stuiver, Swart, Swart, Swart, Vauclair, Vautard, Veizer, Waple, Watanabe, Willenz, Winter, Wolf-Christian Dullo, Wörheide, Wörheide, Zeebe, Zhong   +81 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report

Gynecologic Oncology Reports, 2017
We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus.
Sarah V. Strickland, Mark R. Kilgore, Elise J. Simons, Mara H. Rendi   +3 more
doaj   +1 more source

Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with ...
Jae Yong Yoon, Dong Heon Yang, Hyun Jun Cho, Nam Kyun Kim, Chang-Yeon Kim, Jihyun Son, Jae-Hyung Roh, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae   +12 more
doaj   +1 more source

CA 125 in seminal plasma: correlation with semen parameters [PDF]

, 2017
Ovarian cancer marker CA 125 was measured in human seminal plasma, and the concentrations ranged between 22 and 1149 U/ml, and between 39 and 4711 U/ejaculate.
Bischof, P., Campana, A., Meisser, A.
core  

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study [PDF]

, 2017
Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal condition with a variable disease trajectory. The aim of this study was to evaluate potential biomarkers that predict outcome for people with IPF.
Antoniou, Argueso, Chekmasova, Collard, Dai, Das, Evans, Fingerlin, Greene, Jenkins, Kim, King, Kodama, Le Jeune, Ley, Mackinnon, Maher, McCormack, Noble, Poruk, Reck, Richards, Richeldi, Rosas, Rusanov, Saini, Seibold, Tzouvelekis, Vancheri, White, Wolters, Xiang, Yang   +32 more
core   +1 more source