Results 81 to 90 of about 2,901,202 (236)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Serum biomarkers (CA 15-3, CEA) and hormonal receptor status as predictors of breast cancer recurrence

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Breast cancer is a heterogenous malignancy and is one of the leading causes of cancer-related mortality in women worldwide. Recurrence as a barrier to long-term survivorship and effective patient management is a formidable challenge.
Muntaha Maddah Al Alouci, Fatima Mallallah Mohammed, Zainab M. Qassam, Osama A. Mohsein   +3 more
doaj   +1 more source

Serum miR-16 and CA15.3 combination as early diagnostic biomarkers for breast cancer in Egyptian females [PDF]

Egyptian Journal of Pure and Applied Science
Background: Breast cancer (BC) represents one of the most lethal malignancies among women worldwide. MiRNAs play an important role in breast cancer diagnosis and progression. Inconsistent data about the expression level of miR-16 was reported in BC, thus
Sara Kamal, Doaa Ibrahim, Reham Elshimy, Walid Zahran   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Serum NSE, CEA, CT, CA 15-3 Levels in Human Lung Cancer

The International Journal of Biological Markers, 1990
The significance of neuron specific enolase (NSE) was investigated in comparison with other tumor markers (CEA, CT, CA 15-3) used in the diagnosis and treatment monitoring of lung cancer.
S. Nutini, G. Cappelli, A. Benucci, C. Catalani, F. Nozzoli   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Time Series measurements of White Blood Cells (WBC) and plasma Cancer Antigen 15-3 (CA 15-3) in a patient with metastatic breast cancer, serving as a reference for assessing the clinical relevance of different clustering algorithms.

Applied Medical Informatics
Clustering is highly valuable for analyzing cancer marker time series data. In a recent study, the significance of the K-means clustering algorithm was examined for the first time in evaluating time-series measurements of plasma Cancer Antigen 15-3 (CA ...
Alexandros CLOUVAS
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Correction: Novel sensor for the determination of CA 15-3 in serum of breast cancer patients based on Fe-gallic acid complex doped in modified cellulose polymer thin films. [PDF]

RSC Adv, 2023
AlGhamdi HA, AlZahrani YM, Alharthi S, Mohy-Eldin MS, Mohamed EH, Sheta SM, El-Sheikh SM, Mahmoud SA, Attia MS.   +8 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source