Results 61 to 70 of about 3,242,059 (273)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Combined use of CA 125 and CA 15-3 in patients with endometrial carcinoma
, 1994 Serum levels of CA 125 and CA 15-3 were measured in 148 patients with primary endometrial carcinoma. CA 125-positive levels were found in 33 and 22% of the cases using a cutoff of 35 and 65 U/ml, respectively.
G. Ferrandina +9 more
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Značenje tumorskog markera Ca 15-3
, 2004 In the postoperative course of breast tumor treatment, along with regular ultrasound and radiological assessments, measurements of tumor marker CA 15-3 levels are also used.
Juzbašić, Stjepan +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 1937 Programma del concerto di musica da camera eseguito, la sera del 15 settembre 1937, dal quartetto Poltronieri (Alberto Poltronieri - 1. violino, Ercole Giaccone - 2.
A, A
core
, 2021 Background: Breast cancer makes the major burden of carcinomas in females. Timely diagnosis and treatment is the key. CA 15-3 is a tumour marker which is useful in diagnosis as well as prognosis of breast cancer.
Sameep Garg +2 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Applied Medical InformaticsCancer Antigen 15-3 (CA 15-3) is a glycoprotein commonly linked to breast cancer. Monitoring CA 15-3 levels is crucial for tracking disease progression and evaluating treatment response in patients with metastatic breast cancer. Although fluctuations in
Alexandros CLOUVAS
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