Results 51 to 60 of about 1,275,165 (296)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Hawaii Deep Water Cable Program phase II : cable construction specification [PDF]
, 1985 This document constitutes a detailed construction specification covering the design, fabrication and testing of the preferred 250 MW dc self contained oil filled (SCOF) cable to be used for the laboratory and possibly at-sea portions of the U.S ...
Pirelli Cable Corporation
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Determination of the Cable Span and Cable Deflection of Cable-Driven Parallel Robots
, 2017 S.106-116In this paper, a method is proposed to compute the so-called cable span, i.e. the space occupied by the cables when the robot is moving within its workspace. As the cables are attached to a mostly fixed point on the robot frame, the shape of the
Andreas Pott, Pott, Andreas
core +1 more source
Performance Optimization of Cable⁃Driven Parallel System Considering Center of Mass of Platform
Nanjing Hangkong Hangtian Daxue XuebaoForce controllable workspace （FCWS） and system stiffness are important performance of cable-driven parallel system. When the center of mass of movable platform deviates from its centroid position， extra torque will be generated， which adversely affects ...
BAI Mengxuan +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano +11 more
wiley +1 more source
Hawaii Deep Water Cable Program, phase II : cable catenary study [PDF]
, 1986 The "catenary" study for the Hawaii Deep Water cable (HDWC) Program is applicable to the environmental conditions that cable No. 116 will experience at the bottom of the Alenuihaha Channel.
Pirelli Cable Corporation and Societa Cavi Pirelli
core
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Optimization and design of a cable driven upper arm exoskeleton [PDF]
, 2009 This paper presents the design of a wearable upper arm exoskeleton that can be used to assist and train arm movements of stroke survivors or subjects with weak musculature.
Brackbill, E.A. +9 more
core +1 more source
Workspace Analysis and Dynamic Modeling of 6-DoF Multi-Pattern Cable-Driven Hybrid Mobile Robot
MachinesA cable-driven hybrid mobile robot is a kind of robot consisting of two modules connected in series, which uses multiple parallel cables to drive the moving platforms.
Jiahao Song +4 more
doaj +1 more source