Results 51 to 60 of about 1,901,736 (244)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Accuracy Improvement for CDPRs Based on Direct Cable Length Measurement Sensors

open access: yes, 2021
S.348-359In many applications of cable-driven parallel robots (CDPRs), accuracy is an important requirement. The accuracy of CDPRs with a controller based only on the standard kinematic model is limited because of effects like cable elongation.
Marc Fabritius   +7 more
core   +1 more source

Workspace Analysis and Dynamic Modeling of 6-DoF Multi-Pattern Cable-Driven Hybrid Mobile Robot

open access: yesMachines
A cable-driven hybrid mobile robot is a kind of robot consisting of two modules connected in series, which uses multiple parallel cables to drive the moving platforms.
Jiahao Song   +4 more
doaj   +1 more source

Comprehensive Compensation Method for Motion Trajectory Error of End-Effector of Cable-Driven Parallel Mechanism

open access: yesMachines, 2023
The accuracy of the end-effector motion trajectory is a critical performance indicator for cable-driven parallel mechanisms. This study aims to address the problem of trajectory error during the end-effector motion in a cable-driven parallel mechanism ...
Yanglong Li   +4 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

Efficient calibration of cable-driven parallel robots with variable structure

open access: yes, 2022
S.113-128This paper presents an efficient practical approach for the combined explicit and implicit approximated calibration of cable-driven parallel robots (wire robots, CDPR) mainly developed to tackle the problems with variable system structures, i.e.
Bremer, N.   +2 more
core   +1 more source

Modeling and control of a bedside cable-driven lower-limb rehabilitation robot for bedridden individuals

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Individuals with acute neurological or limb-related disorders may be temporarily bedridden and unable to go to the physical therapy departments. The rehabilitation training of these patients in the ward can only be performed manually by therapists ...
Daoyu Wang   +7 more
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

open access: yesFEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn   +2 more
wiley   +1 more source

Implementing extended kinematics of a cable-driven parallel robot in real-time

open access: yes, 2022
S.287-298This paper describes the implementation of extended pulley kinematics for parallel cable robots. An algorithm for the extended kinematics taking into account cable pulleys is discussed and implemented in real-time.
Pott, Andreas, Schmidt, Valentin
core   +1 more source

Equilibrium Conformation of a Novel Cable-Driven Snake-Arm Robot under External Loads

open access: yesMicromachines, 2022
Based on the anti-parallelogram mechanism, an approximate cylindrical rolling joint is proposed to develop a novel cable-driven snake-arm robot with multiple degrees of freedom (DOF).
Long Huang   +3 more
doaj   +1 more source

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