Results 51 to 60 of about 54,220 (246)

The novel long noncoding RNA CRART16 confers cetuximab resistance in colorectal cancer cells by enhancing ERBB3 expression via miR-371a-5p

Cancer Cell International, 2020
Background Long noncoding RNAs (lncRNAs) have been shown to participate in multiple biological processes and confer drug resistance. However, it remains unclear whether lncRNAs are involved in conferring cetuximab resistance in colorectal cancer (CRC ...
Xiaoqian Zhang, Long Wen, Shanwen Chen, Junling Zhang, Yongchen Ma, Jianwen Hu, Taohua Yue, Jingui Wang, Jing Zhu, Dingfang Bu, Xin Wang   +10 more
doaj   +1 more source

Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier. [PDF]

PLoS ONE, 2016
C. albicans is a commensal yeast of the mucous membranes in healthy humans that can also cause disseminated candidiasis, mainly originating from the digestive tract, in vulnerable patients.
Marianne Goyer, Alicia Loiselet, Fabienne Bon, Coralie L'Ollivier, Michael Laue, Gudrun Holland, Alain Bonnin, Frederic Dalle   +7 more
doaj   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Extracellular Signals of a Human Epithelial Colorectal Adenocarcinoma (Caco-2) Cell Line Facilitate the Penetration of Pseudomonas aeruginosa PAO1 Strain through the Mucin Layer

Frontiers in Cellular and Infection Microbiology, 2017
Pseudomonas aeruginosa can penetrate the layer of mucus formed by host intestinal epithelial cells, often resulting in sepsis in immunocompromised patients. We have previously demonstrated that P.
Naoki Hayashi, Atsushi Yokotani, Masami Yamamoto, Mariko Kososhi, Mayu Morita, Chiaki Fukunishi, Nagisa Nishizawa, Naomasa Gotoh   +7 more
doaj   +1 more source

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

BMC Biotechnology, 2020
Background Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver.
Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki   +5 more
doaj   +1 more source

Carnosine activates the CREB pathway in Caco-2 cells [PDF]

Cytotechnology, 2017
Imidazole dipeptide, carnosine, is a versatile compound composed of β-Ala and L-His. A recent study showed that carnosine might benefit the treatment of Alzheimer's disease and the maintenance of cognitive function. Based on the observation that carnosine is immediately degraded by serum carnosinase, we hypothesized that carnosine improves brain ...
Kaoru, Fujii, Kayoko, Abe, Keishi, Kadooka, Takashi, Matsumoto, Yoshinori, Katakura   +4 more
openaire   +2 more sources

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Expression pattern of Dkk-3, a secreted Wnt pathway inhibitor, in mouse intestinal tissue and three-dimensional cultured Caco-2 spheroids

Journal of Stem Cells and Regenerative Medicine, 2015
We investigated the expression pattern of Dkk-3, a secreted Wnt pathway inhibitor, in mouse intestinal tissue and three-dimensional cultured Caco-2 spheroids. Dkk-3 was expressed at the bottom of crypts from the mouse small intestine.
Kataoka K, Rikitake Y, Ayabe Y
doaj  

Two‐Dimensional Carrier Gas at Diamond and Cubic Boron Nitride (111) Interface: Role of Interfacial Bonding and Defects

Advanced Electronic Materials, EarlyView.
The study identifies four bonding configurations at the (111) diamond/c‐BN interface, where B or N atoms bond with either one or three carbon atoms. C‐B bonds create two‐dimensional (2D) hole gases, while C–N bonds create electron gases. Three‐C‐bonded interfaces show three times higher carrier density than one‐C‐bonded interfaces.
Shikha Saini, Konstantin Klyukin, Mengren Bill Liu, Mark J. Polking, Bilge Yildiz   +4 more
wiley   +1 more source

Construction of Caco-2 cell hollow fiber bioreactor for the study on functional substances

浙江大学学报. 农业与生命科学版, 2016
Human colon carcinoma cell line Caco-2 has been extensively used over the last thirty years as a model of the intestinal barrier. The parental cell line undergoes a process of spontaneous differentiation that leads to the formation of a monolayer of ...
XU Dongdong, CHU Qiang, YANG Yunyun, LÜ Xiangmin, ZHANG Yanzhen, ZHENG Xiaodong   +5 more
doaj   +1 more source