Results 241 to 250 of about 187,576 (310)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis.

JAMA Netw Open
Deng Z, Li J, Ji R, Delgado JR, Yim SHL, Kachuri L, Cardenas A, Graff RE, Leppert JT, Dennis LK, Chung BI, Langston ME.   +11 more
europepmc   +1 more source

Application of Zinc Ferrite Nanoparticles for the Magnetic Removal of Algae That Bind Cadmium. [PDF]

Nanomaterials (Basel)
Koska P, Fóris T, Gráczer K, Állné Ilosvai ÁM, Kristály F, Daróczi L, Vanyorek L, Viskolcz B.   +7 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Acidification, warming and cadmium exposure disrupt zebrafish calcium metabolism, bone formation and swimming activity. [PDF]

J Exp Biol
Geessinck QF, Dimitriadis RI, Gorissen M, Klaren PHM, Obers MJW, Verberk WCEP, Zethof J, Metz JR.   +7 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Screening for Periodontitis Using Blood Biomarkers and Demographic Data: A Machine Learning Study. [PDF]

Oral Health Prev Dent
Choi S, Oh D, Rashed R, Hemadeh R, Kim YJ, Oyoyo U.   +5 more
europepmc   +1 more source

Cadmium chloride administered through drinking water disrupts the gut-liver axis through intestinal barrier failure, endoplasmic reticulum stress, and PIEZO1 signaling in broiler chickens. [PDF]

Poult Sci
Imad EF, Salaheddine K, Bakr MA, Rahim MF, Li S, Nawaz S, Ijaz F, Jin C, Li J.   +8 more
europepmc   +1 more source

The Effect and Molecular Mechanism of <i>Fto</i> Gene Knockout on Cadmium-Induced Injury in Pancreatic β-Cells. [PDF]

Curr Issues Mol Biol
Yang S, Li W, Ma S, Xu N, Shen K, Yuan J, Hu Y, Gu S, He Z.   +8 more
europepmc   +1 more source