Results 101 to 110 of about 148,951 (345)

CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering

Genetics, 2016
The advent of genome editing techniques based on the clustered regularly interspersed short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the biological sciences. CRISPR is quickly becoming an indispensible experimental tool for
D. Dickinson, B. Goldstein
semanticscholar   +1 more source

The Caenorhabditis elegans Lifespan Machine [PDF]

Nature Methods, 2013
The measurement of lifespan pervades aging research. Because lifespan results from complex interactions between genetic, environmental and stochastic factors, it varies widely even among isogenic individuals. The actions of molecular mechanisms on lifespan are therefore visible only through their statistical effects on populations.
Walter Fontana, Bryne Ulmschneider, Nicholas Stroustrup, Javier Apfeld, Zachary M. Nash, Isaac F. López-Moyado   +5 more
openaire   +3 more sources

NECROTIC NEURODEGENERATION IN CAENORHABDITIS ELEGANS

TheScientificWorldJOURNAL, 2001
Necrosis plays a central role in neuronal injury associated with stroke and ischemia. Unlike apoptotic cell death, little is understood of molecular mechanisms of necrosis. The two distinct forms of cell death, necrosis and apoptosis, are easily distinguishable by morphological characteristics in the nematode Caenorhabditis elegans.
Monica Driscoll, Keli Xu, Beate Gerstbrein   +2 more
openaire   +3 more sources

Advanced Contactless Bioassembly Approaches: Leveraging Sound, Optical, and Magnetic Fields

Advanced NanoBiomed Research, EarlyView.
This review explores innovative contactless bioassembly techniques driven by sound, light, and magnetic fields, which enable the precise organization of cells, biomaterials, and bioactive substances into complex 3D structures. These technologies, crucial for in vitro modeling and regenerative medicine, are examined in detail, highlighting their ...
Micaela Natta, Greta Cocchi, Riccardo Tognato, Alessandro Cianciosi, Tiziano Serra   +4 more
wiley   +1 more source

First person – Éva Saskői

Disease Models & Mechanisms, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Éva Saskői is first author on ‘The SDHB Arg230His
doaj   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Caenorhabditis elegans as a Model for Microbiome Research

Frontiers in Microbiology, 2017
The nematode Caenorhabditis elegans is used as a central model system across biological disciplines. Surprisingly, almost all research with this worm is performed in the absence of its native microbiome, possibly affecting generality of the obtained ...
Fan Zhang, Maureen Berg, Katja Dierking, M. Félix, M. Shapira, B. Samuel, H. Schulenburg   +6 more
semanticscholar   +1 more source

Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Accepted Article.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

A Review on Luminescent Benzoselenadiazole Derivatives: Comparison with Benzothiadiazoles, Properties, Applications, and Trends

Chemistry – An Asian Journal, EarlyView.
This review explores the photophysical behavior and bioimaging applications of luminescent benzoselenadiazole (BSD) derivatives, in comparison with benzothiadiazole (BTD) analogues. Emerging trends highlight BSDs as promising tools in advanced phototechnology.
Brenno A. D. Neto, John Spencer, Alexandre A. M. Lapis   +2 more
wiley   +1 more source