Results 121 to 130 of about 100,650 (200)

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Volume 24, Issue 5, May 2025.
We found that reducing insulin signalling in adult worms slows down their reproductive ageing and extends their lifespan without negative side effects. Moreover, combining it with IF further enhances these benefits. These interventions likely work by regulating genes linked to biosynthesis and immunity, showing how optimising gene expression can delay ...
Zahida Sultanova, Aykut Shen, Katarzyna Hencel, Hanne Carlsson, Zoe Crighton, Daniel Clifton, Alper Akay, Alexei A. Maklakov   +7 more
wiley   +1 more source

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, Volume 24, Issue 5, May 2025.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Negative Effect of Gst‐35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk‐1 and Skr Genes

Aging Cell, EarlyView.
The overexpression of gst‐35, the mammalian orthologous genes GSTA1, GSTA2, and GSTA3, induces lysosomal dysfunction through the genes pmk‐1 and skr in C. elegans. This overexpression not only promotes an in vivo inflammatory response and accumulation of reactive oxygen species but also significantly shortens the nematode lifespan; inhibits its ...
Yehui Gao, Xinyun Zhang, Congmin Wei, Hongru Lin, Mengchen Wu, Botian Ma, Jinyun Jiang, Shan Li, Hongbing Wang   +8 more
wiley   +1 more source

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

Aging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom, Hyejin Mun, Jinhwan Lim, Yoo Lim Chun, Kyung‐Won Min, Johana Lambert, L. Ashley Cowart, Jason S. Pierce, Besim Ogretmen, Jung‐Hyun Cho, Jeong Ho Chang, J. Ross Buchan, Jason Pitt, Matt Kaeberlein, Sung‐Ung Kang, Eun‐Soo Kwon, Seungbeom Ko, Kyoung‐Min Choi, Yong Sun Lee, Yoon‐Su Ha, Seung‐Jin Kim, Kwang‐Pyo Lee, Hyo‐Sung Kim, Seo Young Yang, Chang Hoon Shin, Je‐Hyun Yoon, Kyu‐Sun Lee   +26 more
wiley   +1 more source

HLH‐30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron–Sulfur Cluster Biosynthesis Pathways

Aging Cell, EarlyView.
Proteostasis enhancing treatments are potential therapies for many age‐related diseases. We discovered that interference with the CoA biosynthesis pathway and limiting iron‐sulfur cluster availability improve proteostasis in C. elegans. Proteostasis improvement under these conditions depends on the conserved HLH‐30/TFEB transcription factor, which ...
Rewayd Shalash, Dror Michael Solomon, Mor Levi‐Ferber, Henrik von Chrzanowski, Mohammad Khaled Atrash, Barak Nakar, Matan Yosef Avivi, Hagit Hauschner, Aviya Swisa, Alicia Meléndez, Yaron Shav‐Tal, Sivan Henis‐Korenblit   +11 more
wiley   +1 more source

Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G{alpha}q and excitable cells in C. elegans [PDF]

, 2003
Garcia, L. Rene, Iwasaki, Kouichi, Khan, Liakot A., Moghal, Nadeem, Sternberg, Paul W.   +4 more
core   +1 more source

Alternate Day Fasting Enhances Intestinal Epithelial Function During Aging by Regulating Mitochondrial Metabolism

Aging Cell, EarlyView.
Alternate day fasting alleviates aging‐induced intestinal epithelial barrier damage by regulating mitochondrial metabolism in small intestinal stem cells. ABSTRACT With advancing age, the decline in intestinal stem cell (ISC) function can lead to a series of degenerative changes in the intestinal epithelium, a critical factor that increases the risk of
Heng Quan, Yao Lu, Yingying Lin, Peng Xue, Yuning Zhang, Yuqi Wang, Weiru Yu, Xiaoya Lin, Wuqi Yang, Cong Lv, Yafei Zhang, Fazheng Ren, Huiyuan Guo   +12 more
wiley   +1 more source

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes

Aging Cell, EarlyView.
Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age‐related sarcopenia, a condition characterized by muscle mass loss. Through the creation of three‐dimensional models of mitochondria from quadriceps muscle tissue taken from old and young humans, a loss in mitochondrial complexity was observed to ...
Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian‐qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton   +52 more
wiley   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

AI‐Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorhabditis elegans

Aging Cell, EarlyView.
A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, Peter O. Fedichev   +5 more
wiley   +1 more source