Results 141 to 150 of about 100,650 (200)
Microbial amyloids in neurodegenerative amyloid diseases
The FEBS Journal, Volume 292, Issue 6, Page 1265-1281, March 2025.Numerous microbes, including those indigenous to the human microbiome, produce amyloidogenic proteins. These proteins have critical functions in bacterial physiology and their lifestyles. Emerging evidence indicates that microbial amyloids also interact directly or indirectly with host‐derived amyloid proteins, such as those which underlie Parkinson's ...
Timothy Sampson
wiley +1 more source
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo +2 more
wiley +1 more source
The FEBS Journal, EarlyView.The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley +1 more source
Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16
The FEBS Journal, EarlyView.To investigate the impact of dietary components on animal growth, an Escherichia coli single‐gene deletion library was screened using the Caenorhabditis elegans growth model. Thirty‐four E. coli mutants were identified to delay worm development. Notably, E.
Min Feng +3 more
wiley +1 more source
Regulation of physiological and pathological condensates by molecular chaperones
The FEBS Journal, EarlyView.Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree +5 more
wiley +1 more source
The FEBS Journal, EarlyView.The microbiota plays a major role in metazoan physiology, particularly in the intestinal tract. Nonetheless, its extreme complexity hinders functional studies. Taking advantage of the Caenorhabditis elegans and Escherichia coli model systems, Feng et al. report the physiological effect of purine biosynthesis deficiencies in E.
José Eduardo Gomes
wiley +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
Transcription‐coupled repair: tangled up in convoluted repair
The FEBS Journal, EarlyView.In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher +3 more
wiley +1 more source
The Investigation of Microbe-Nematode Interactions [PDF]
, 2013 Crepeau, Chelsea K.
core +1 more source
The FEBS Journal, EarlyView.Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch +1 more
wiley +1 more source