Results 161 to 170 of about 100,650 (200)

Mass spectrometry reveals age‐dependent collagen decline in murine atria

Annals of the New York Academy of Sciences, EarlyView.
Using mass spectrometry, we analyzed the atrial ECM of young (12 weeks) and old (77 weeks) C57BL/6J mice. Results showed a marked decrease in collagen content with age, alongside increases in specific ECM‐related proteins (e.g., MMP9, S100A9, VWA3A).
Nathalie Ringström, Charlotte Edling, Giovanna Nalesso, Javier Barallobre‐Barreiro, Kamalan Jeevaratnam   +4 more
wiley   +1 more source

OsLC1, a transaldolase, regulates cell patterning and leaf morphology through modulation of secondary metabolism

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1751-1767, May 2025.
Summary Leaf morphogenesis is a crucial process in plants that governs essential physiological functions such as photosynthesis and transpiration. Despite significant advances in understanding leaf development, the mechanism of intricate cellular patterning remains elusive.
Sha Wu, Lianfu Tian, Shasha Guo, Han Lei, Xinjie Zhao, Xiaohua Hao, Shaozhuang Li, Zijing Xie, Wenli Hu, Liqun Huang, Ying Tan, Xueying Long, Dongping Li   +12 more
wiley   +1 more source

Localising enzymes to biomolecular condensates increases their accumulation and benefits engineered metabolic pathway performance in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The establishment of Nicotiana benthamiana as a robust biofactory is complicated by issues such as product toxicity and proteolytic degradation of target proteins/introduced enzymes. Here we investigate whether biomolecular condensates can be used to address these problems. We engineered biomolecular condensates in N.
Anya L. Lindström Battle, Angus W. Barrett, Mark D. Fricker, Lee J. Sweetlove   +3 more
wiley   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Biogenesis and reformation of synaptic vesicles

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic vesicle proteins are axonally transported in precursor vesicles (PVs) before conversion into mature synaptic vesicles (SVs) that are reformed by local recycling at synapses. Abstract Communication within the nervous system relies on the calcium‐triggered release of neurotransmitter molecules by exocytosis of synaptic ...
Svenja Bolz, Volker Haucke
wiley   +1 more source

Ultrastructure of astrocytes using volume electron microscopy: A scoping review

The Journal of Physiology, EarlyView.
Abstract figure legend A complete overview on astrocyte ultrastructure with volume electron microscopy. The morphology of astrocytes under physiological and pathological conditions plays a role in brain homeostasis, synaptic activity and structural support, but their morphological complexity and heterogeneity are still poorly quantified.
Vanessa Chiappini, Maria Fernanda Veloz Castillo, Francesco Biancardi, Ferdinando Di Cunto, Pierre J. Magistretti, Alessandro Vercelli, Marco Agus, Corrado Calì   +7 more
wiley   +1 more source

Cell lineage tracing: Methods, applications, and challenges

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cell lineage tracing is a crucial technique for understanding cell fate and lineage relationships, with wide applications in developmental biology, tissue regeneration, and disease progression studies. Over the years, experimental cell lineage tracing methods have advanced from early labeling techniques to modern genetic tools such as CRISPR ...
Shanjun Mao, Chenyang Zhang, Runjiu Chen, Shan Tang, Xiaodan Fan, Jie Hu   +5 more
wiley   +1 more source

Computational systems biology approaches to cellular aging—Integrating network maps and dynamical models

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley   +1 more source

Dissection of Behavioral Components and the Role of Omega/Delta Turns for the Chemotaxis of C. elegans

Genes to Cells, Volume 30, Issue 4, July 2025.
The analyses of centerline‐based posture dynamics of C. elegans during chemotaxis indicated that directional turns are achieved in a two‐step process: (1) selection of the sequence type (at least in the case of single turns) and (2) adjustment of the turning angle within the selected turn type (for a backward turn to a forward turn).
Karin Suwazono, Koyo Kuze, Ukyo T. Tazawa, Moon Sun Jang, Hirofumi Kunitomo, Yu Toyoshima, Yuichi Iino   +6 more
wiley   +1 more source

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

Annals of Neurology, Volume 97, Issue 6, Page 1134-1143, June 2025.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa, Umberto Manera, Rosario Vasta, Grazia Zocco, Francesca Di Pede, Sara Cabras, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Emilio Minerva, Luca Sbaiz, Maura Brunetti, Salvatore Gallone, Maurizio Grassano, Enrico Matteoni, Giulia Polverari, Giuseppe Fuda, Federico Casale, Paolina Salamone, Giovanni De Marco, Giulia Marchese, Cristina Moglia, Andrea Calvo, Marco Pagani, Adriano Chiò   +24 more
wiley   +1 more source