Results 161 to 170 of about 148,951 (345)

Nano Zinc Oxide Toxicity Varies With Age and Sex in Panagrellus redivivus

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT ZnO NPs can adsorb onto soil particles and potentially enter groundwater. Nematodes and other soil microfauna are vital to the soil's health and nutrient cycles, yet they are seriously endangered by ZnO NPs. A dose–response study using Panagrellus redivivus was applied.
Lola Virág Kiss   +4 more
wiley   +1 more source

Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration

open access: yesVIEW, EarlyView.
Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim   +8 more
wiley   +1 more source

Seeing the Unseen: Structured Illumination Microscopy for Organelles Dynamics

open access: yesVIEW, EarlyView.
Abstract Super‐resolution microscopy (SRM) has revolutionized the field of biological imaging by surpassing the diffraction limit of light and rendering us the ability to visualize cellular structures and processes at unprecedented resolution. This powerful technique enables the observation of nanoscale details, thereby providing insights into ...
Adrian Tan   +4 more
wiley   +1 more source

Plastamination: A Rising Concern for Parkinson's Disease

open access: yes
Movement Disorders, EarlyView.
Roberto Erro   +2 more
wiley   +1 more source

Host avoidance and resistance vary independently and are specific to parasite genotype

open access: yesJournal of Animal Ecology, EarlyView.
Hosts may defend themselves against parasites by avoiding contact or by mounting a resistance defense after contact. This study shows that avoidance and resistance are highly specific across nematode host and bacterial parasite strain pairings, but avoidance and resistance do not covary across host strains.
Caroline R. Amoroso   +3 more
wiley   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

open access: yesAging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji   +15 more
wiley   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

open access: yesAging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang   +8 more
wiley   +1 more source

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