Results 171 to 180 of about 100,650 (200)

Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change

BioEssays, Volume 47, Issue 6, June 2025.
Cell shape changes underlie animal development, physiology, and disease. The cell surface is mechanosensitive to the microenvironment and cytoskeleton activities, which generate plasma membrane topographies recognized and affected by Arp2/3 actin network induction pathways to remodel cell shape during immune cell migration, neural progenitor cell ...
Tony J. C. Harris
wiley   +1 more source

Glutamatergic Regulation of miRNA‐Containing Intraluminal Vesicle Trafficking and Extracellular Vesicle Secretion From Cortical Neurons

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Neuronal extracellular vesicles (microvesicles and exosomes) are emerging secreted vesicular signals that play important roles in the CNS. Currently, little is known about how glutamatergic signalling affects the subcellular localisation of exosome precursor intraluminal vesicles (ILVs), microRNA (miR) packaging into ILVs and in vivo spreading
Marcela Bertolio, Qiyi Li, Francesca E. Mowry, Kathryn E. Reynolds, Rashed Alananzeh, Haichao Wei, Kyoeun Keum, Rachel Jarvis, Jiaqian Wu, Yongjie Yang   +9 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
The tetrasaccharide linkage region of proteoglycans is synthesized through a series of well‐controlled enzymatic reactions in nature. The expression, activity, and substrate profile of these biosynthetic enzymes and the latest development of chemoenzymatic synthesis of linkage region‐bearing glycopeptides are summarized in this review.
Po‐han Lin, Xuefei Huang
wiley   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, Volume 15, Issue 5, Page 738-753, May 2025.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, Volume 12, Issue 18, May 15, 2025.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Optogenetics in Caenorhabditis elegans

2015
With a compact neural circuit consisting of entirely mapped 302 neurons, Caenorhabditis elegans plays an important role in the development and application of optogenetics. Optogenetics in C. elegans offers the opportunity that drastically changes experimental designs with increasing accessibility for neural activity and various cellular processes ...
Ikue Mori, Yuki Tsukada
openaire   +2 more sources

Paramyosin of Caenorhabditis elegans

Journal of Molecular Biology, 1974
Abstract Paramyosin has been isolated from the nematode, Caenorhabditis elegans . Its identity has been established by a variety of criteria, including purification, molecular weight, immunological cross reactivity with known paramyosin and formation of characteristic paracrystals.
Henry F. Epstein, Henry F. Epstein, Sydney Brenner, Robert H. Waterston   +3 more
openaire   +3 more sources

Networks in Caenorhabditis elegans

Current Opinion in Genetics & Development, 2011
The network paradigm has become a pervasive theme in biology over the last decade, as increasingly large functional genomic datasets are being collected to interrogate regulatory influences, physical interactions, and genetic dependencies between genes, transcripts, and proteins.
Kahn Rhrissorrakrai, Kristin C. Gunsalus
openaire   +3 more sources