Results 241 to 250 of about 121,076 (308)

Specific genes of the dopaminergic (dop-3) and serotonergic (tph-1) pathways contribute to the effects of ethanol consumption in Caenorhabditis elegans. [PDF]

PLoS One
Rubio-Tomás T, Hunn CA, Hajdú G, Sőti C, Tavernarakis N, Barta C.   +5 more
europepmc   +1 more source

Challenging and diagnosing structured population models by testing predictions from stochastic demography

Methods in Ecology and Evolution, Volume 17, Issue 7, Page 2234-2252, July 2026.
Abstract Structured population models are parameterized to accurately project expected population sizes, stage/state distributions and population growth rates, but they also predict the variation in outcomes among individuals, such as the variance and skewness of lifetime reproductive output (LRO) and lifespan, the probability of never reproducing, and
Stephen P. Ellner, Robin E. Snyder, Daniel T. Blumstein, Dylan Z. Childs, Joshua C. Fowler, Christina M. Hernández, Julien G. A. Martin, María Paniw, Yngvild Vindenes   +8 more
wiley   +1 more source

Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation. [PDF]

Mol Biol Evol
Yamakawa S, Barf LM, Hejnol A.
europepmc   +1 more source

Proteostasis Rebalancing by LET‐607 Deficiency Promotes Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
LET‐607 enforces a trade‐off between UPRER and UPRcyto in C. elegans, maintaining a proteostatic balance optimized for development but suboptimal for longevity. LET‐607 deficiency suppresses UPRER but activates UPRcyto via attenuation of one‐carbon metabolism and H3K9 methylation, thereby enhancing cytosolic proteostasis and extending lifespan ...
Haixiang Tong, Wei Li, Pangui Yuan, Feng Li, Qin Liu, Shanshan Pang, Haiqing Tang   +6 more
wiley   +1 more source

Jujube Polysaccharide Promotes Neuroprotection and Longevity in <i>Caenorhabditis elegans</i> Through Oxidative Stress Resistance and Stress-Response Signaling. [PDF]

Int J Mol Sci
Hou Z, Ahmed A, Wang J, Sun M, Wang F, Wang Q.   +5 more
europepmc   +1 more source

Suppression of Ciliogenesis Alleviates Cellular Senescence via AKT Signaling in Gingival Aging

Aging Cell, Volume 25, Issue 7, July 2026.
In human gingival aging, aged gingival fibroblasts show increased senescence with enhanced primary cilia formation. Targeting cilia formation by knocking down IFT88 could reverse fibroblast senescence via the AKT signaling and alleviate periodontal inflammation.
Wenjun Shao, Huihui Yang, Chenghu Yin, Yunjie Zhang, Yixing Xu, Wakam Chang, Haibin Xia, Min Wang, Liangliang Fu, Kaiyao Huang   +9 more
wiley   +1 more source

Utilizing <i>Caenorhabditis elegans</i> as an <i>In Vivo</i> Model for Identifying Small Molecules Modulating Lipid Metabolism: A Guideline. [PDF]

Prev Nutr Food Sci
Teng Z, Kim AT, Shen P, Chung S, Park Y.
europepmc   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Complete Mitochondrial Genome with Phylogenetic Analyses of a New <i>Caenorhabditis</i> Species from Ta Kou Nature Reserve, Vietnam. [PDF]

Zool Stud
Dang VD, Hsu JC, Wang J.
europepmc   +1 more source

Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug‐Like Agents Against Angiostrongylus cantonensis

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Cynnamoyl benzylpiperazine was identified as drug‐like derivative of cinnarizine with anthelmintic activity against A. cantonensis. In this work, 15 out of 31 derivatives showed improved anthelmintic activity with increased solubility. A SAR study was carried out to determine the molecular features involved in such effect.
Bruna L. Lemes, Mariana A. Siegl‐Breno, Marina T. Varela, Flavia B. Lopes, Mikaelly K. Silva‐Nunes, Thaiane D. Santos, Lucas Fukui‐Silva, Daniel B. Roquini, Vinicius G. Maltarollo, Josué de Moraes, João Paulo S. Fernandes   +10 more
wiley   +1 more source