Results 61 to 70 of about 100,650 (200)

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Predicting Phenotypic Diversity and the Underlying Quantitative Molecular Transitions [PDF]

, 2009
During development, signaling networks control the formation of multicellular patterns. To what extent quantitative fluctuations in these complex networks may affect multicellular phenotype remains unclear.
A Abzhanov, A Colman-Lerner, A Dayarian, Anand R. Asthagiri, AS Yoo, C Nusslein-Volhard, CA Giurumescu, CA Giurumescu, Christopher Rao, CJ Tomlin, Claudiu A. Giurumescu, D Volfson, E Meir, EL Ferguson, G von Dassow, GJ Beitel, GT Reeves, I Greenwald, I Salazar-Ciudad, IS Greenwald, J Doebley, J Fisher, J Fisher, J Kimble, J Liu, JE Sulston, JE Sulston, K Amonlirdviman, K Kiontke, L Qiao, M Cui, M Pribyl, M Wang, MA Felix, MA Felix, MB Elowitz, MS Samoilov, Paul W. Sternberg, PW Sternberg, PW Sternberg, RJ Hill   +40 more
core   +3 more sources

Optogenetic mutagenesis in Caenorhabditis elegans [PDF]

Nature Communications, 2015
AbstractReactive oxygen species (ROS) can modify and damage DNA. Here we report an optogenetic mutagenesis approach that is free of toxic chemicals and easy to perform by taking advantage of a genetically encoded ROS generator. This method relies on the potency of ROS generation by His-mSOG, the mini singlet oxygen generator, miniSOG, fused to a ...
Noma, Kentaro, Jin, Yishi
openaire   +5 more sources

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Neurogenesis in Caenorhabditis elegans

GENETICS
Abstract Animals rely on their nervous systems to process sensory inputs, integrate these with internal signals, and produce behavioral outputs. This is enabled by the highly specialized morphologies and functions of neurons. Neuronal cells share multiple structural and physiological features, but they also come in a large diversity of ...
Richard J Poole, Nuria Flames, Luisa Cochella   +2 more
openaire   +3 more sources

Caenorhabditis elegans par genes [PDF]

Current Biology, 2002
What are they? Six par genes (par-1 through par-6) have been identified in Caenorhabditis elegans. Loss-of-function mutations in any par locus results in loss of anterior–posterior (AP) asymmetries during the first two embryonic cell divisions. This results in a failure to restrict developmental regulators to specific embryonic cells, mitotic spindle ...
José-Eduardo Gomes, Bruce Bowerman
openaire   +3 more sources

Two New Cases Expand the Phenotypic Spectrum of TUBG1 Missense Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The gamma‐tubulin ring complex (γ‐TuRC) plays a role in coordinating centrosome and spindle pole body formation during cell division. TUBG1 encodes a critical component of the γ‐TuRC. Pathogenic TUBG1 variants can cause a range of alterations in cortical gyral patterning, microcephaly, and other neurological manifestations.
Roser Urreizti, Jessica Vissicchio, Mohamed Idries, Monica Cozar, Raquel Rabionet, Tyhiesia Donald, Elizabeth J. Bhoj, Tomoki T. Nomakuchi, Shannon C. Shipley, Andrew E. Timms, Ghayda M. Mirzaa, Mercedes Serrano, Andrew K. Sobering   +12 more
wiley   +1 more source

The Multilayer Connectome of Caenorhabditis elegans

PLOS Computational Biology, 2016
Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function and occurs primarily outside the synaptic connectome.
Bentley, Barry, Branicky, Robyn, Barnes, Christopher L, Chew, Yee Lian, Yemini, Eviatar, Bullmore, Edward T, Vértes, Petra E, Schafer, William R   +7 more
openaire   +9 more sources

Advanced Contactless Bioassembly Approaches: Leveraging Sound, Optical, and Magnetic Fields

Advanced NanoBiomed Research, EarlyView.
This review explores innovative contactless bioassembly techniques driven by sound, light, and magnetic fields, which enable the precise organization of cells, biomaterials, and bioactive substances into complex 3D structures. These technologies, crucial for in vitro modeling and regenerative medicine, are examined in detail, highlighting their ...
Micaela Natta, Greta Cocchi, Riccardo Tognato, Alessandro Cianciosi, Tiziano Serra   +4 more
wiley   +1 more source

Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant [PDF]

, 2016
In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants.
Braeckman, Bart, Depuydt, Geert, Dhondt, Ineke, Rasulova, Madina, Shanmugam, Nilesh   +4 more
core   +2 more sources