Results 81 to 90 of about 148,951 (345)
Optogenetic mutagenesis in Caenorhabditis elegans [PDF]
Nature Communications, 2015 AbstractReactive oxygen species (ROS) can modify and damage DNA. Here we report an optogenetic mutagenesis approach that is free of toxic chemicals and easy to perform by taking advantage of a genetically encoded ROS generator. This method relies on the potency of ROS generation by His-mSOG, the mini singlet oxygen generator, miniSOG, fused to a ...
Noma, Kentaro, Jin, Yishi
openaire +5 more sources
Advanced Science, EarlyView.Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing +4 more
wiley +1 more source
A Microbial Metagenome ( sp.) in Whole Genome Sequences
Bioinformatics and Biology Insights, 2013 DNA of apparently recent bacterial origin is found in the genomic sequences of Caenorhabditis angaria and Caenorhabditis remanei. Here we present evidence that the DNA belongs to a single species of the genus Leucobacter (high-GC Gram+Actinobacteria ...
Riccardo Percudani
doaj +1 more source
Neurogenesis in Caenorhabditis elegans
GENETICSAbstract Animals rely on their nervous systems to process sensory inputs, integrate these with internal signals, and produce behavioral outputs. This is enabled by the highly specialized morphologies and functions of neurons. Neuronal cells share multiple structural and physiological features, but they also come in a large diversity of ...
Richard J Poole +2 more
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Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids
Advanced Science, EarlyView.This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu +9 more
wiley +1 more source
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Genetics, 2017 Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into ...
J. Watts, M. Ristow
semanticscholar +1 more source
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source
Radiation Medicine and Protection, 2021 Objective: Under the guidance of model organism Caenorhabditis elegans with fine olfactory system, small molecular metabolites sensitive to high dose radiation were screened as biomarkers of acute radiation-induced injury, and their metabolic pathways ...
Xin Wu +4 more
doaj
Assembly of the Caenorhabditis elegans gut microbiota from diverse soil microbial environments
The ISME Journal, 2016 It is now well accepted that the gut microbiota contributes to our health. However, what determines the microbiota composition is still unclear. Whereas it might be expected that the intestinal niche would be dominant in shaping the microbiota, studies ...
Maureen Berg +7 more
semanticscholar +1 more source
Caenorhabditis elegans par genes [PDF]
Current Biology, 2002 What are they? Six par genes (par-1 through par-6) have been identified in Caenorhabditis elegans. Loss-of-function mutations in any par locus results in loss of anterior–posterior (AP) asymmetries during the first two embryonic cell divisions. This results in a failure to restrict developmental regulators to specific embryonic cells, mitotic spindle ...
José-Eduardo Gomes, Bruce Bowerman
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