Results 261 to 270 of about 193,403 (293)

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, Volume 15, Issue 5, Page 738-753, May 2025.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, Volume 12, Issue 18, May 15, 2025.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Experimental modeling of Alzheimer's disease: Translational lessons from cross‐taxon analyses

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract Alzheimer's disease (AD) is a severely debilitating neurodegenerative disease with a rapidly increasing global prevalence, poorly understood causes, and no efficient treatments. Experimental models are valuable for studying AD pathogenesis, including amyloid beta and tau accumulation, synaptic dysfunction, and neuroinflammation. While no model
Konstantin B. Yenkoyan, Maria M. Kotova, Kirill V. Apukhtin, David S. Galstyan, Tamara G. Amstislavskaya, Tatyana Strekalova, Murilo S. de Abreu, Vergine A. Chavushyan, Lee Wei Lim, Longen Yang, Denis D. Rosemberg, Allan V. Kalueff   +11 more
wiley   +1 more source

RNA‐Based Biopesticides: Pioneering Precision Solutions for Sustainable Aquaculture in China

Animal Research and One Health, Volume 3, Issue 2, Page 165-176, May 2025.
The Chinese dragon represents RNA biopesticides, which effectively counteract bacterial, viral, and parasitic threats, safeguarding aquatic life. This method is precise, focusing solely on harmful agents and sparing beneficial aquaculture species. Its innovative nature protects aquatic environments while reducing ecological footprint.
Yiran Huang, Yingmin Dai, Zhuotong Huang, Mengqi Zhang, Lijun Xiu, Xianhui Zhang, Youyu Zhang, Lixing Huang   +7 more
wiley   +1 more source

Bioactive Ingredients, Functions, and Development Strategies of Phascolosoma esculenta—An Edible Marine Organism: A Review

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
Phascolosoma esculenta is an invertebrate living in the ocean's intertidal zone, belonging to the phylum Sipuncula, and is often cooked as a delicious snack in China's coastal areas. It is often referred to as the “sea ginseng” because of its high nutritional value and the efficacy of enhancing endurance.
Lingxuan Chen, Wen Xu, Rui Zhu, Shaohua Xu, Lixia Chen, Hua Li   +5 more
wiley   +1 more source

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Nature, 2003
Coleen T Murphy, Steven A Mccarroll, Cornelia I Bargmann   +2 more
exaly   +2 more sources

Caenorhabditis elegans

CABI Compendium, 2022
This datasheet on Caenorhabditis elegans covers Identity, Distribution, Hosts/Species Affected, Natural Enemies, Further Information.

semanticscholar   +1 more source

The structure of the nervous system of the nematode Caenorhabditis elegans.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1986
The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections.
J. White, Erica L. Southgate, J. Thomson, S. Brenner   +3 more
semanticscholar   +1 more source