Results 211 to 220 of about 136,487 (292)

From Coffee Alkaloid to Ovarian Targets: An Integrated Computational Framework for Trigonelline in Ovarian Aging

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
This study employs an integrative in silico approach combining network pharmacology, molecular docking, and molecular dynamics simulations to explore the molecular association between trigonelline and ovarian aging, identifying five hub proteins (MMP9, JAK2, PARP1, HDAC1, and CYP3A4) and three major mechanistic axes related to extracellular matrix ...
Woon Shin Yong   +4 more
wiley   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés   +13 more
wiley   +1 more source

Metal‐Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 620-632, February 2026.
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
Nilvea Ramalho de Oliveira   +4 more
wiley   +1 more source

Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005–2010 and 2015–2016

open access: yesGeoHealth, Volume 10, Issue 2, February 2026.
Abstract The associations of polybrominated diphenyl ethers (PBDEs) with biological aging are unclear. This study explores the possible relationship between PBDEs and accelerated aging. Cross‐sectional data from 6,091 subjects of the National Health and Nutrition Examination Survey (NHANES) 2005–2010 and 2015–2016 are analyzed.
Yan Chen   +3 more
wiley   +1 more source

QuickProt: A Fast and Accurate Homology‐Based Protein Annotation Tool for Non‐Model Organisms to Advance Comparative Genomics

open access: yesMolecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT The rapid growth of genome sequencing has outpaced the development of efficient annotation tools, especially for species lacking transcriptome data. To address this challenge, we present QuickProt, a fast, accurate and user‐friendly homology‐based protein annotation tool.
Guisen Chen   +8 more
wiley   +1 more source

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in <i>Caenorhabditis elegans,</i> challenges a proposed role in heme trafficking. [PDF]

open access: yesElife
Sandkuhler SE   +11 more
europepmc   +1 more source

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