Results 211 to 220 of about 1,676,429 (284)

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source

Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging

Aging Cell, Volume 25, Issue 9, September 2026.
The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang, Jinyuan Niu, Xiaoyu Hu, Zhiang Hu, Yuan Gao, Jialiang Liu, Ning Chen, Yaomin Hu   +7 more
wiley   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, Volume 36, Issue 5, September 2026.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Functional Characterization of Loss of <i>RNF43</i> Reveals Neuronal Defects in a <i>Caenorhabditis elegans</i> Model. [PDF]

Int J Mol Sci
Sonmez K, Güzel S, Kazan HH, Ekim B, Kaya C, Turkyilmaz Z, Karabulut R, Ergun MA.   +7 more
europepmc   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Network Pharmacology-Based Study of Citrus medica L. Ethanol Extract Combating Obesity in Caenorhabditis elegans via Dual Action on AAK-2/NHR-49 and MDT-15/SBP-1 Pathways. [PDF]

Chem Biodivers
Zhao F, Shi G, Liu R, Xu Z, Jiang Y, Wang Y, Zhang X, Wang H.   +7 more
europepmc   +1 more source

Virulent Parasites Emerge in Hosts With Rising Temperatures

Global Change Biology, Volume 32, Issue 9, September 2026.
Using experimental evolution we explored the short‐term trajectory of parasite evolution—at the phenotypic and genomic scales—across environmentally relevant temperatures in a thermally mismatched host–parasite interaction. Our findings suggest that shifting environmental temperatures will leave phenotypic and genomic signatures on evolving parasites ...
Tobias E. Hector, Julia M. Kreiner, James C. Forward, Kim L. Hoang, Emily J. Stevens, Serena Johnson, Jingdi Li, Kayla C. King   +7 more
wiley   +1 more source

Caenorhabditis elegans as an Alternative Model in Pharmacological and Toxicological Studies Involving Microplastics. [PDF]

Water Environ Res
Moura PHM, de Britto Sá ME, Amorim JCG, Santos RG, de Souza JB, Silva DMRR, Dos Santos Barreto M, Dos Santos Pacheco PG, Lisboa JS, Borges LP, Guimarães AG.   +10 more
europepmc   +1 more source