Results 221 to 230 of about 8,207 (238)

Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

Current Medicinal Chemistry, 2019
Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the disease. Indeed, chronic diabetes hyperglycemia is often associated with severe long-term complications including cardiovascular symptoms, retinopathy, nephropathy, and neuropathy.
PITTALA', Valeria, SALERNO, Loredana, ROMEO, Giuseppe, ACQUAVIVA R, DI GIACOMO, Claudia, SORRENTI, Valeria   +5 more
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Effect of caffeic acid phenethyl ester on corneal neovascularization in rats

Current Eye Research, 2001
Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal ...
Osman Çekiç, Ahmet Gültek, Erdinç Aydin, Kenan Daglioglu, Mehmet Borazan, Yüksel Totan, Mutlu Cihan Daglioglu   +6 more
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Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

Inflammation, 2008
Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related ...
Tevfik Küçükkartallar, Ahmet Tekin, Adil Kartal, Serdar Turkyilmaz, Burhan Ates, Ayhan Dinckan, Hasan Esen, Hüseyin Yilmaz   +7 more
openaire   +3 more sources

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndrome

Inflammation, 2010
The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) on inflammatory and related histopathological changes in the lung and liver in experimental hepatopulmonary syndrome (HPS) model. Forty Sprague Dawley rats were used in this study. The animals were divided into four groups of ten rats each.
Murat Çakir, Hüseyin Yilmaz, Serdar Turkyilmaz, Adil Kartal, Tevfik Küçükkartallar, Ahmet Tekin, Burhan Ates, Ilhan Ciftci, Hasan Esen   +8 more
openaire   +3 more sources

The effects of caffeic acid phenethyl ester on retina in a diabetic rat model

Cutaneous and Ocular Toxicology, 2021
We aimed to investigate the effect of caffeic acid phenethyl ester (CAPE) on retinal apoptosis and oxidative stress parameters in streptozotocin (STZ) induced diabetic rat model.This study included 3 groups; control, STZ, and STZ + CAPE. The rats in STZ, and STZ + CAPE groups were injected with STZ (35 mg/kg, i.p.) for induction of diabetes. In the STZ 
Alparslan Şahin, Savaş Kaya, Mukadder Baylan   +2 more
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Effect of caffeic acid phenethyl ester on cartilage in experimental osteoarthritis

Rheumatology International, 2002
Activation of nuclear factor kappa B (NF-kappaBeta) in synovial cells is seen in RA and OA patients. Caffeic acid phenethyl ester (CAPE) is a specific and potent inhibitor of NF-kappaBeta. We aimed to determine the in vivo effects of intra-articular injections of CAPE on cartilage in an experimental rabbit osteoarthritis (OA) model.
Nurzat Elmalı, Biilent Mizrak, Arslan Bora, İrfan Ayan, Burak Germen, Yusuf Turkoz   +5 more
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Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties

International Journal of Food Sciences and Nutrition, 2011
Caffeic acid phenethyl ester (CAPE), a plant polyphenolic concentrated in honeybee propolis, has been found to be biologically active in a variety of pathways. The aim of this study was to determine the antioxidant activity of CAPE using different methods such as total antioxidant activity by the thiocyanate method, 2,2'-azino-bis(3-ethylbenzthiazoline-
Gocer, Hulya, Gulcin, Ilhami
openaire   +6 more sources

Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?

Current Medicinal Chemistry
Background: Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti- inflammatory properties and potential therapeutic applications. Objectives: This narrative review explores the potential utility of CAPE in cancer treatment.
Bjørklund, Geir, Storchylo, Olha, Peana, Massimiliano, Hangan, Tony, Lysiuk, Roman, Lenchyk, Larysa, Koshovyi, Oleh, Antonyak, Halyna, Hudz, Nataliia, Chirumbolo, Salvatore   +9 more
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Caffeic acid phenethyl ester as an adjuvant therapy for advanced prostate cancer

Medical Hypotheses, 2013
Prostate cancer is the second most frequently diagnosed cancer of men. Androgen ablation therapy is the primary treatment for metastatic prostate cancer. However, the majority of prostate cancer patients receiving the androgen ablation therapy will ultimately develop recurrent castration-resistant tumors within 3 years. Chemotherapy shows little effect
Chun-Chieh Liu, Chun-Chieh Liu, Jong-Ming Hsu, Chih-Pin Chuu, Chih-Pin Chuu, Li-Kuo Kuo   +5 more
openaire   +3 more sources

The protective role of caffeic acid phenethyl ester against streptomycin ototoxicity

American Journal of Otolaryngology, 2013
The aim of this experimental study was to investigate the efficacy of caffeic acid phenethyl ester (CAPE) in the prevention of streptomycin-induced ototoxicity.Thirty-two adult Wistar albino rats were divided into 4 groups: control (n = 8), streptomycin (n = 8), CAPE (n = 8), and streptomycin + CAPE (n = 8).
Salih Bakir, Ayşenur Keleş, Ramazan Gun, Vefa Kinis, Abdurrahman Abakay, Osman Gökalp, İsmail Topçu, Musa Özbay, Ediz Yorgancilar   +8 more
openaire   +3 more sources