Results 101 to 110 of about 265,014 (287)

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Neural Network‐Based Detection of Adulterants in Opioid Samples Using IR Absorption Spectroscopy

Drug Testing and Analysis, EarlyView.
We construct a neural network for the classification of bromazolam and fluorofentanyl in illicit opioid samples. The model outperforms a random forest classifier and shows elevated performance for low concentration samples. ABSTRACT Community‐based drug checking services are challenged in their ability to reliably detect low concentration adulterants ...
Joshua Jai, Lea Gozdzialski, Bruce Wallace, Chris G. Gill, Dennis Hore   +4 more
wiley   +1 more source

Short- and long-term neurobehavioural impairments in mice offspring following chronic perinatal caffeine exposure and withdrawal

BMC Neuroscience
This study explored neurodevelopmental and adult neurobehavioural outcomes in mouse offspring following chronic perinatal caffeine exposure and subsequent withdrawal.
Funmilayo Eniola Olopade, Oluwabusayo Racheal Folarin, Taidinda Tashara Gilbert, James Olukayode Olopade   +3 more
doaj   +1 more source

Catechins and Caffeine Inhibit Fat Accumulation in Mice through the Improvement of Hepatic Lipid Metabolism

Journal of Obesity, 2012
To elucidate the inhibiting mechanisms of fat accumulation by catechins, caffeine, and epigallocatechin gallate (EGCG), ICR mice were fed diets containing either 0.3% catechins or 0.1% EGCG and/or 0.05% caffeine for 4 weeks.
Chikako Sugiura, Shiho Nishimatsu, Tatsuya Moriyama, Sayaka Ozasa, Teruo Kawada, Kazutoshi Sayama   +5 more
doaj   +1 more source

The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts [PDF]

, 1998
We have analyzed the role of the protein kinase Chk1 in checkpoint control by using cell-free extracts from Xenopus eggs. Recombinant Xenopus Chk1 (Xchk1) phosphorylates the mitotic inducer Cdc25 in vitro on multiple sites including Ser-287.
Dunphy, William G., Emami, Katayoon H., Guo, Zijian, Kumagai, Akiko, Wang, Sophie X.   +4 more
core   +1 more source

Multivariate linear regression to predict association of non‐invasive arterial stiffness with cardiovascular events

ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.
Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi, Mostafa Eslamiyeh, Amin Mansoori, Eisa Nazar, Maryam Alinezhad‐Namaghi, Reza Rezvani, Majid Ghayour‐Mobarhan, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mark Ghamsary   +10 more
wiley   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Principal Components Analysis of Spot Urine Caffeine and Caffeine Metabolites Identifies Promising Exposure Biomarkers of Caffeine and Theobromine Intake in a Cross-Sectional Survey of the United States Population (National Health and Nutrition Examination Survey 2009–2014)

Current Developments in Nutrition
Background: Spot urine concentrations of caffeine and certain caffeine metabolites correlate well with 24-h caffeine intake and have potential use as caffeine exposure biomarkers.
Ching-I Pao, Michael E Rybak, Maya R Sternberg   +2 more
doaj   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

Effects of Caffeine on Cardiovascular Toxicity in Adult Wistar Rats

Journal of Applied Sciences and Environmental Management
Caffeine has been used for thousands of years. When taken in excess, caffeine can have negative effects on the body's overall health, including the cardiovascular system.
B. P. Onyeije, S. O. Innih
doaj